Pld6 MGI Mouse Gene Detail - MGI:2687283 - phospholipase D family member 6

Symbol

Pld6
Name

phospholipase D family member 6
Synonyms

4933433K01Rik, mitoPLD, Zuc

Feature Type

protein coding gene
IDs

MGI:2687283
NCBI Gene: 194908
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:59674723-59678471 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.79 cM
Mapping Data

3 experiments

SNPs within 2kb

179 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2687283	protein coding gene	Chr11:59674719-59678483 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018405	protein coding gene	Chr11:59634196-59637945 (-)
A/J	MGP_AJ_G0018374	protein coding gene	Chr11:57359714-57363460 (-)
AKR/J	MGP_AKRJ_G0018344	protein coding gene	Chr11:59281452-59285309 (-)
BALB/cJ	MGP_BALBcJ_G0018345	protein coding gene	Chr11:57708414-57712162 (-)
C3H/HeJ	MGP_C3HHeJ_G0018158	protein coding gene	Chr11:59148674-59152420 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018797	protein coding gene	Chr11:61526962-61530710 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016443	protein coding gene	Chr11:54603832-54607470 (-)
CAST/EiJ	MGP_CASTEiJ_G0017715	protein coding gene	Chr11:59290969-59294715 (-)
CBA/J	MGP_CBAJ_G0018132	protein coding gene	Chr11:64211063-64214809 (-)
DBA/2J	MGP_DBA2J_G0018241	protein coding gene	Chr11:57023375-57027123 (-)
FVB/NJ	MGP_FVBNJ_G0018232	protein coding gene	Chr11:56681931-56685679 (-)
LP/J	MGP_LPJ_G0018314	protein coding gene	Chr11:60232756-60236505 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018256	protein coding gene	Chr11:65313471-65317253 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018838	protein coding gene	Chr11:59306116-59309898 (-)
PWK/PhJ	MGP_PWKPhJ_G0017486	protein coding gene	Chr11:57618672-57622491 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017278	protein coding gene	Chr11:59100011-59103808 (-)
WSB/EiJ	MGP_WSBEiJ_G0017766	protein coding gene	Chr11:58985335-58989097 (-)

Human Ortholog

PLD6, phospholipase D family member 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLD6, phospholipase D family member 6
Synonyms

ZUC
Links

HGNC:30447

NCBI Gene ID: 201164

neXtProt AC: NX_Q8N2A8

UniProt: Q8N2A8
Chr Location

17p11.2; chr17:17200995-17206333 (-) GRCh38

MGI Vertebrate Homology

Pld6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLD6
Gene Tree

Pld6

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

1 involving Pld6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display male infertility with arrest of male meiosis and mitochondrial abnormalities.

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All GO Annotations

25
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pld6

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All Sequences

39
RefSeq

5
UniProt

1
CCDS

CCDS70199.1

Ensembl

ENSMUSG00000043648 (Evidence)
NCBI Gene

194908

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043648	Ensembl Gene Model \| MGI Sequence Detail	3749	C57BL/6J	± kb
transcript	ENSMUST00000125307	Ensembl \| MGI Sequence Detail	948	Not Applicable
polypeptide	ENSMUSP00000115503	Ensembl \| MGI Sequence Detail	221	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000012848 phospholipase D6

(term hierarchy)
PDB

4GGJ, 4GGK
EC

3.1.4.-
InterPro Domains

IPR051406 Phospholipase D domain-containing protein

IPR025202 Phospholipase D-like domain

IPR001736 Phospholipase D/Transphosphatidylase

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All nucleic 16

cDNA 16

Microarray probesets 4

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MGI:2684856

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:293837 Izumi N, et al., Zucchini consensus motifs determine the mechanism of pre-piRNA production. Nature. 2020 Feb;578(7794):311-316

TSS for Pld6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108245	Chr11:59678462-59678509 (-)	-15 bp
Tssr108244	Chr11:59678139-59678148 (-)	327 bp
Tssr108243	Chr11:59678110-59678121 (-)	355 bp
Tssr108242	Chr11:59678095-59678109 (-)	369 bp
Tssr108241	Chr11:59678061-59678070 (-)	405 bp
Tssr108240	Chr11:59678036-59678057 (-)	424 bp
Tssr108239	Chr11:59678018-59678027 (-)	448 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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