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Mkx Gene Detail
Summary
  • Symbol
    Mkx
  • Name
    mohawk homeobox
  • Synonyms
    9430023B20Rik, Irxl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687286
    NCBI Gene: 210719
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:6934966-7004779 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 4.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1840 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2687286
 protein coding gene Chr18:6934518-7004780 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024133
 protein coding gene Chr18:3799240-3899407 (-)
A/J MGP_AJ_G0024095
 protein coding gene Chr18:3819312-3915537 (-)
AKR/J MGP_AKRJ_G0024063
 protein coding gene Chr18:3885210-3984664 (-)
BALB/cJ MGP_BALBcJ_G0024095
 protein coding gene Chr18:3764424-3865017 (-)
C3H/HeJ MGP_C3HHeJ_G0023861
 protein coding gene Chr18:3786228-3881518 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024540
 protein coding gene Chr18:4051835-4154037 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021979
 protein coding gene Chr18:3545145-3637968 (-)
CAST/EiJ MGP_CASTEiJ_G0023339
 protein coding gene Chr18:3789187-3884681 (-)
CBA/J MGP_CBAJ_G0023834
 protein coding gene Chr18:3962166-4071203 (-)
DBA/2J MGP_DBA2J_G0023962
 protein coding gene Chr18:3664790-3762102 (-)
FVB/NJ MGP_FVBNJ_G0023928
 protein coding gene Chr18:3662189-3753836 (-)
LP/J MGP_LPJ_G0024046
 protein coding gene Chr18:3814887-3920083 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023956
 protein coding gene Chr18:4093411-4198422 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024585
 protein coding gene Chr18:3763450-3863458 (-)
PWK/PhJ MGP_PWKPhJ_G0023084
 protein coding gene Chr18:3720985-3818756 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022895
 protein coding gene Chr18:4028711-4121233 (-)
WSB/EiJ MGP_WSBEiJ_G0023405
 protein coding gene Chr18:3733855-3832173 (-)



Homology
more
  • Human Ortholog
    MKX, mohawk homeobox
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MKX, mohawk homeobox
  • Synonyms
    C10orf48, IFRX, IRXL1
  • Links
    NCBI Gene ID: 283078
    neXtProt AC: NX_Q8IYA7
    UniProt: Q8IYA7

  • Chr Location
    10p12.1; chr10:27672874-27746060 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 4 alleles in 4 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit thin, hypoplastic tendons with reduced tensile strength.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    886
  • Tissues
    133
  • cDNA Data
    18
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 210719 NCBI Gene Model | MGI Sequence Detail 69814 C57BL/6J ±  kb
    transcript NM_177595 RefSeq | MGI Sequence Detail 3201 ZRU/MplStud  
    polypeptide Q8BIA3 UniProt | EBI | MGI Sequence Detail 353 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 18
      Primer pair 5
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 19
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:349911 Wang Y, et al., The Mohawk homeobox gene represents a marker and osteo-inhibitory factor in calvarial suture osteoprogenitor cells. Cell Death Dis. 2024 Jun 17;15(6):420
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory