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H2-M10.6 Gene Detail
Summary
  • Symbol
    H2-M10.6
  • Name
    histocompatibility 2, M region locus 10.6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687364
    NCBI Gene: 399549
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr17:37123067-37126458 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.16 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2687364
 protein coding gene Chr17:37123063-37126458 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023681
 protein coding gene Chr17:37159126-37162523 (+)
A/J MGP_AJ_G0023639
 protein coding gene Chr17:35988658-35992051 (+)
AKR/J MGP_AKRJ_G0023610
 protein coding gene Chr17:36421542-36424935 (+)
BALB/cJ MGP_BALBcJ_G0023646
 protein coding gene Chr17:36232330-36235720 (+)
C3H/HeJ MGP_C3HHeJ_G0023408
 protein coding gene Chr17:36936996-36940389 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024084
 protein coding gene Chr17:38761126-38764556 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0023385
 protein coding gene Chr17:40268212-40271605 (+)
DBA/2J MGP_DBA2J_G0023510
 protein coding gene Chr17:35383161-35387117 (+)
FVB/NJ MGP_FVBNJ_G0023483
 protein coding gene Chr17:34992310-34995703 (+)
LP/J MGP_LPJ_G0023587
 protein coding gene Chr17:37693498-37696895 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023506
 protein coding gene Chr17:39069116-39072509 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024129
 protein coding gene Chr17:36760155-36765160 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HLA-B, major histocompatibility complex, class I, B
  • Vertebrate Orthologs
    13
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-B, major histocompatibility complex, class I, B
  • Synonyms
    AS, B-4901, HLAB
  • Links
    NCBI Gene ID: 3106
    neXtProt AC: NX_P01889
    UniProt: P01889

  • Chr Location
    6p21.33; chr6:31353872-31367067 (-)  GRCh38
  • Human Ortholog
    HLA-C, major histocompatibility complex, class I, C
  • Synonyms
    D6S204, HLAC, HLA-JY3, HLC-C, MHC, PSORS1
  • Links
    NCBI Gene ID: 3107
    neXtProt AC: NX_P10321
    UniProt: P10321

  • Chr Location
    6p21.33; chr6:31268749-31272130 (-)  GRCh38
  • Human Ortholog
    HLA-E, major histocompatibility complex, class I, E
  • Synonyms
    HLA-6.2, QA1
  • Links
    NCBI Gene ID: 3133
    neXtProt AC: NX_P13747
    UniProt: P13747

  • Chr Location
    6p22.1; chr6:30489509-30494194 (+)  GRCh38
  • Human Ortholog
    HLA-F, major histocompatibility complex, class I, F
  • Synonyms
    CDA12, HLA-5.4, HLA-CDA12, HLAF
  • Links
    NCBI Gene ID: 3134
    neXtProt AC: NX_P30511
    UniProt: P30511

  • Chr Location
    6p22.1; chr6:29722775-29738532 (+)  GRCh38
  • Human Ortholog
    HLA-G, major histocompatibility complex, class I, G
  • Synonyms
    MHC-G
  • Links
    NCBI Gene ID: 3135
    neXtProt AC: NX_P17693
    UniProt: P17693

  • Chr Location
    6p22.1; chr6:29826474-29831125 (+)  GRCh38
Human Diseases
more
  • Diseases
    45 with human HLA-A,HLA-B,HLA-C,HLA-E,HLA-G associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    52
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 399549 NCBI Gene Model | MGI Sequence Detail 3392 C57BL/6J ±  kb
transcript NM_201611 RefSeq | MGI Sequence Detail 1405 C57BL/6  
polypeptide NP_963905 RefSeq | MGI Sequence Detail 330 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR050208 Antigen-presenting and immune regulatory MHC class I-related
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
Molecular
Reagents
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  • All nucleic 1
    cDNA 1

    Microarray probesets 1
References
more
  • Summaries
    All 15
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:82444 Loconto J, et al., Functional Expression of Murine V2R Pheromone Receptors Involves Selective Association with the M10 and M1 Families of MHC Class Ib Molecules. Cell. 2003 Mar 7;112(5):607-18
  • Latest
    J:207447 Leinders-Zufall T, et al., A family of nonclassical class I MHC genes contributes to ultrasensitive chemodetection by mouse vomeronasal sensory neurons. J Neurosci. 2014 Apr 9;34(15):5121-33
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory