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Tmt1a2 Gene Detail
Summary
  • Symbol
    Tmt1a2
  • Name
    thiol methyltransferase 1A2
  • Synonyms
    Mettl7a2, Ubie
  • Feature Type
    protein coding gene
  • IDs
    MGI:3026615
    NCBI Gene: 393082
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr15:100251081-100259700 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.27 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    436 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3026615
 protein coding gene Chr15:100251081-100259721 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0022285
 protein coding gene Chr15:101187494-101204929 (+)
BALB/cJ MGP_BALBcJ_G0022314
 protein coding gene Chr15:98334521-98350718 (+)
C3H/HeJ MGP_C3HHeJ_G0022084
 protein coding gene Chr15:101295323-101303256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022761
 protein coding gene Chr15:106053394-106062085 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020287
 protein coding gene Chr15:94047054-94052469 (+)
CAST/EiJ MGP_CASTEiJ_G0021608
 protein coding gene Chr15:102136918-102149114 (+)
CBA/J MGP_CBAJ_G0022053
 protein coding gene Chr15:109766152-109783377 (+)
DBA/2J MGP_DBA2J_G0022179
 protein coding gene Chr15:97580141-97594032 (+)
FVB/NJ MGP_FVBNJ_G0022160
 protein coding gene Chr15:96573758-96582313 (+)
LP/J MGP_LPJ_G0022251
 protein coding gene Chr15:102380979-102398484 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022180
 protein coding gene Chr15:113517221-113527060 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022776
 protein coding gene Chr15:101285399-101294901 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0021658
 protein coding gene Chr15:101819523-101827963 (+)



Homology
more
  • Human Ortholog
    TMT1A, thiol methyltransferase 1A
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMT1A, thiol methyltransferase 1A
  • Synonyms
    AAM-B, AAMB, METTL7A
  • Links
    NCBI Gene ID: 25840
    neXtProt AC: NX_Q9H8H3
    UniProt: Q9H8H3

  • Chr Location
    12q13.12; chr12:50923472-50932510 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Genomic Mutations
    3 involving Tmt1a2
  • Find Mice (IMSR)
    2 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 393082 NCBI Gene Model | MGI Sequence Detail 8620 C57BL/6J ±  kb
transcript NM_199477 RefSeq | MGI Sequence Detail 1808 Not Specified  
polypeptide NP_955771 RefSeq | MGI Sequence Detail 244 Not Specified  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
Other
Accession IDs
less
MGI:7461485
References
more
  • Summaries
    All 33
    Diseases 1
    Gene Ontology 2
    Phenotypes 20
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory