Cdin1 MGI Mouse Gene Detail - MGI:3026886 - CDAN1 interacting nuclease 1

Symbol

Cdin1
Name

CDAN1 interacting nuclease 1
Synonyms

BC052040, MGC:62402

Feature Type

protein coding gene
IDs

MGI:3026886
NCBI Gene: 399568
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:115412197-115609249 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 58.18 cM
Mapping Data

2 experiments

SNPs within 2kb

4218 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3026886	protein coding gene	Chr2:115411388-115609263 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026305	protein coding gene	Chr2:118135798-118337667 (+)
A/J	MGP_AJ_G0026266	protein coding gene	Chr2:113350671-113551438 (+)
AKR/J	MGP_AKRJ_G0026245	protein coding gene	Chr2:116493612-116700393 (+)
BALB/cJ	MGP_BALBcJ_G0026279	protein coding gene	Chr2:113588098-113787321 (+)
C3H/HeJ	MGP_C3HHeJ_G0026024	protein coding gene	Chr2:116929054-117131884 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026726	protein coding gene	Chr2:122042124-122248180 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024106	protein coding gene	Chr2:108465267-108666849 (+)
CAST/EiJ	MGP_CASTEiJ_G0025487	protein coding gene	Chr2:117228235-117437922 (+)
CBA/J	MGP_CBAJ_G0026001	protein coding gene	Chr2:126339272-126552271 (+)
DBA/2J	MGP_DBA2J_G0026140	protein coding gene	Chr2:112778989-112977946 (+)
FVB/NJ	MGP_FVBNJ_G0026102	protein coding gene	Chr2:111621921-111820232 (+)
LP/J	MGP_LPJ_G0026241	protein coding gene	Chr2:118442293-118648130 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026121	protein coding gene	Chr2:130772181-130980357 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026781	protein coding gene	Chr2:116604377-116807671 (+)
PWK/PhJ	MGP_PWKPhJ_G0025223	protein coding gene	Chr2:112327453-112526987 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025022	protein coding gene	Chr2:115741423-115942641 (+)
WSB/EiJ	MGP_WSBEiJ_G0025556	protein coding gene	Chr2:117420574-117621151 (+)

Human Ortholog

CDIN1, CDAN1 interacting nuclease 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDIN1, CDAN1 interacting nuclease 1
Synonyms

C15orf41, HH114
Links

HGNC:26929

NCBI Gene ID: 84529

neXtProt AC: NX_Q9Y2V0

UniProt: Q9Y2V0
Chr Location

15q14; chr15:36579626-36810248 (+) GRCh38

MGI Vertebrate Homology

Cdin1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDIN1
Gene Tree

Cdin1

Diseases

1 with human CDIN1 associations

				Human Disease	Mouse Models
				congenital dyserythropoietic anemia type Ib IDs congenital dyserythropoietic anemia type Ib DOID:0111397 MESH:D000742 OMIM:615631 UMLS_CUI:C0271933

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
1 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

15
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Cdin1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show normal blastocyst formation but exhibit complete embryonic lethality by E7.5.

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All GO Annotations

9
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

24
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN cdin1

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All Sequences

67
RefSeq

32
UniProt

2
CCDS

CCDS50662.1, CCDS50663.1

Ensembl

ENSMUSG00000040282 (Evidence)
NCBI Gene

399568

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040282	Ensembl Gene Model \| MGI Sequence Detail	197053	C57BL/6J	± kb
transcript	ENSMUST00000166472	Ensembl \| MGI Sequence Detail	2770	Not Applicable
polypeptide	ENSMUSP00000126772	Ensembl \| MGI Sequence Detail	287	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000060139 CDAN1-interacting nuclease 1

(term hierarchy)
InterPro Domains

IPR029404 CDAN1-interacting nuclease 1

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 3

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MGI:6436678

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19462	Chr2:115412132-115412146 (+)	-58 bp
Tssr19463	Chr2:115412148-115412224 (+)	-11 bp
Tssr19464	Chr2:115412246-115412273 (+)	63 bp
Tssr19465	Chr2:115412276-115412303 (+)	93 bp
Tssr19466	Chr2:115429666-115429681 (+)	17,477 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24