Ppp4r2 MGI Mouse Gene Detail - MGI:3027896 - protein phosphatase 4, regulatory subunit 2

Symbol

Ppp4r2
Name

protein phosphatase 4, regulatory subunit 2

Feature Type

protein coding gene
IDs

MGI:3027896
NCBI Gene: 232314
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:100810596-100846891 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 46.93 cM
Mapping Data

3 experiments

SNPs within 2kb

954 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3027896	protein coding gene	Chr6:100810583-100846895 (+)
129S1/SvImJ	no annotation
A/J	MGP_AJ_G0031057	protein coding gene	Chr6:98943104-98978775 (+)
AKR/J	MGP_AKRJ_G0030988	protein coding gene	Chr6:101655814-101694112 (+)
BALB/cJ	MGP_BALBcJ_G0031068	protein coding gene	Chr6:98927577-98945832 (+)
C3H/HeJ	MGP_C3HHeJ_G0030640	protein coding gene	Chr6:82732351-82747679 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031527	protein coding gene	Chr6:105483773-105527994 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028691	protein coding gene	Chr6:96743701-96781212 (+)
CAST/EiJ	MGP_CASTEiJ_G0030175	protein coding gene	Chr6:101914955-101964610 (+)
CBA/J	MGP_CBAJ_G0030754	protein coding gene	Chr6:109534868-109549156 (+)
DBA/2J	MGP_DBA2J_G0030907	protein coding gene	Chr6:98063239-98100237 (+)
FVB/NJ	MGP_FVBNJ_G0030861	protein coding gene	Chr6:97264809-97288791 (+)
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0030895	protein coding gene	Chr6:113285134-113301824 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031554	protein coding gene	Chr6:101564729-101608350 (+)
PWK/PhJ	MGP_PWKPhJ_G0029891	protein coding gene	Chr6:97107973-97123494 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029719	protein coding gene	Chr6:100452070-100490523 (+)
WSB/EiJ	MGP_WSBEiJ_G0030259	protein coding gene	Chr6:102102356-102117003 (+)

Human Ortholog

PPP4R2, protein phosphatase 4 regulatory subunit 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP4R2, protein phosphatase 4 regulatory subunit 2
Synonyms

PP4R2
Links

HGNC:18296

NCBI Gene ID: 151987

neXtProt AC: NX_Q9NY27

UniProt: Q9NY27
Chr Location

3p13

MGI Vertebrate Homology

Ppp4r2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPP4R2
Gene Tree

Ppp4r2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Gene trapped

2
Spontaneous

1
Targeted

5
Genomic Mutations

1 involving Ppp4r2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

28
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

898
Tissues

40
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp4r2

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All Sequences

69
RefSeq

14
UniProt

7
CCDS

CCDS20391.1

Ensembl

ENSMUSG00000052144 (Evidence)
NCBI Gene

232314

			Length	Strain/Species	Flank
genomic	232314	NCBI Gene Model \| MGI Sequence Detail	36296	C57BL/6J	± kb
transcript	NM_001418209	RefSeq \| MGI Sequence Detail	5005	C57BL/6
polypeptide	Q0VGB7	UniProt \| EBI \| MGI Sequence Detail	417	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013155 serine/threonine-protein phosphatase 4 regulatory subunit 2

(term hierarchy)
InterPro Domains

IPR015267 Protein phosphatase 4 core regulatory subunit R2
GlyGen

Q0VGB7 3 sites, 1 N-linked glycan (2 sites), 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 13

Microarray probesets 5

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MGI:3034166

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 14
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ppp4r2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57998	Chr6:100810567-100810624 (+)	0 bp
Tssr57999	Chr6:100811058-100811078 (+)	472 bp
Tssr58000	Chr6:100812242-100812248 (+)	1,649 bp
Tssr58001	Chr6:100816083-100816110 (+)	5,501 bp
Tssr58002	Chr6:100816114-100816118 (+)	5,520 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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