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Mrgprd Gene Detail
Summary
  • Symbol
    Mrgprd
  • Name
    MAS-related GPR, member D
  • Synonyms
    LOC211578, MrgD
  • Feature Type
    protein coding gene
  • IDs
    MGI:3033142
    NCBI Gene: 211578
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:144868572-144877796 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 89.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3033142
 protein coding gene Chr7:144868572-144877823 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033298
 protein coding gene Chr7:150729863-150740425 (+)
A/J MGP_AJ_G0033281
 protein coding gene Chr7:146355128-146365145 (+)
AKR/J MGP_AKRJ_G0033212
 protein coding gene Chr7:150463900-150474802 (+)
BALB/cJ MGP_BALBcJ_G0033281
 protein coding gene Chr7:146114900-146127902 (+)
C3H/HeJ MGP_C3HHeJ_G0032995
 protein coding gene Chr7:150223685-150235434 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033791
 protein coding gene Chr7:156147017-156160258 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030764
 protein coding gene Chr7:147494574-147504042 (+)
CAST/EiJ MGP_CASTEiJ_G0032318
 protein coding gene Chr7:142546179-142555254 (+)
CBA/J MGP_CBAJ_G0032968
 protein coding gene Chr7:161451015-161463969 (+)
DBA/2J MGP_DBA2J_G0033122
 protein coding gene Chr7:144313753-144324317 (+)
FVB/NJ MGP_FVBNJ_G0033069
 protein coding gene Chr7:144268970-144282049 (+)
LP/J MGP_LPJ_G0033214
 protein coding gene Chr7:152287729-152296679 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033104
 protein coding gene Chr7:161989829-162004427 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033809
 protein coding gene Chr7:149422445-149433434 (+)
PWK/PhJ MGP_PWKPhJ_G0032028
 protein coding gene Chr7:137646396-137656206 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031872
 protein coding gene Chr7:136223181-136236131 (+)
WSB/EiJ MGP_WSBEiJ_G0032431
 protein coding gene Chr7:150418824-150428047 (+)



Homology
more
  • Human Ortholog
    MRGPRD, MAS related GPR family member D
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRGPRD, MAS related GPR family member D
  • Synonyms
    MRGD, TGR7
  • Links
    NCBI Gene ID: 116512
    neXtProt AC: NX_Q8TDS7
    UniProt: Q8TDS7

  • Chr Location
    11q13.3; chr11:68980021-68980986 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mrgprd mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 5 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased sensitivity to cold, heat, and mechanical stimuli. Mice for another null allele exhibit dilated cardiomypathy and cardiac dysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    20
  • cDNA Data
    4
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 211578 NCBI Gene Model | MGI Sequence Detail 9225 C57BL/6J ±  kb
    transcript NM_203490 RefSeq | MGI Sequence Detail 3117 C57BL/6  
    polypeptide Q91ZB8 UniProt | EBI | MGI Sequence Detail 321 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 4
      Other 4

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685345
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 4
      Phenotypes 67
    • Earliest
      J:71586 Dong X, et al., A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001 Sep 7;106(5):619-32
    • Latest
      J:353123 Zhang D, et al., C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway. bioRxiv. 2024 Jun 11;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory