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Mfsd4b4 Gene Detail
Summary
  • Symbol
    Mfsd4b4
  • Name
    major facilitator superfamily domain containing 4B4
  • Synonyms
    AA474331
  • Feature Type
    protein coding gene
  • IDs
    MGI:3035041
    NCBI Gene: 213332
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:39766009-39775202 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 21.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    375 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3035041
 protein coding gene Chr10:39766009-39775234 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017154
 protein coding gene Chr10:38418516-38430263 (-)
A/J MGP_AJ_G0017131
 protein coding gene Chr10:37387944-37393403 (-)
AKR/J MGP_AKRJ_G0017091
 protein coding gene Chr10:37909994-37913987 (-)
BALB/cJ MGP_BALBcJ_G0017094
 protein coding gene Chr10:37454839-37460298 (-)
C3H/HeJ MGP_C3HHeJ_G0016914
 protein coding gene Chr10:38237168-38247345 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017552
 protein coding gene Chr10:39594034-39603655 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015249
 protein coding gene Chr10:35385542-35394994 (-)
CAST/EiJ MGP_CASTEiJ_G0016493
 protein coding gene Chr10:38406463-38416404 (-)
CBA/J MGP_CBAJ_G0016888
 protein coding gene Chr10:41419706-41428984 (-)
DBA/2J MGP_DBA2J_G0016993
 protein coding gene Chr10:36914347-36918340 (-)
FVB/NJ MGP_FVBNJ_G0016988
 protein coding gene Chr10:36415085-36424702 (-)
LP/J MGP_LPJ_G0017070
 protein coding gene Chr10:38390069-38399289 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017018
 protein coding gene Chr10:42271774-42278398 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017589
 protein coding gene Chr10:37902632-37906625 (-)
PWK/PhJ MGP_PWKPhJ_G0016274
 protein coding gene Chr10:36754150-36764944 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016058
 protein coding gene Chr10:37708095-37717893 (-)
WSB/EiJ MGP_WSBEiJ_G0016556
 protein coding gene Chr10:38178691-38189373 (-)



Homology
more
  • Human Ortholog
    MFSD4B, major facilitator superfamily domain containing 4B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MFSD4B, major facilitator superfamily domain containing 4B
  • Synonyms
    KIAA1919, NaGLT1, SLC60A2
  • Links
    NCBI Gene ID: 91749
    neXtProt AC: NX_Q5TF39
    UniProt: Q5TF39

  • Chr Location
    6q21; chr6:111259327-111445354 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      43
    • RefSeq
      12
    • UniProt
      2
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 213332 NCBI Gene Model | MGI Sequence Detail 9194 C57BL/6J ±  kb
    transcript NM_001416571 RefSeq | MGI Sequence Detail 4771 C57BL/6  
    polypeptide NP_001371154 RefSeq | MGI Sequence Detail 503 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR011701 Major facilitator superfamily
      IPR036259 MFS transporter superfamily
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4
    Other
    Accession IDs
    less
    MGI:3779435
    References
    more
    • Summaries
      All 20
      Gene Ontology 1
      Phenotypes 9
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory