About   Help   FAQ
Nlrc4 Gene Detail
Summary
  • Symbol
    Nlrc4
  • Name
    NLR family, CARD domain containing 4
  • Synonyms
    9530011P19Rik, Card12, Ipaf
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036243
    NCBI Gene: 268973
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:74733254-74766140 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 45.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036243
 protein coding gene Chr17:74732433-74766140 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024029
 protein coding gene Chr17:77060453-77102896 (-)
A/J MGP_AJ_G0023986
 protein coding gene Chr17:74699770-74732468 (-)
AKR/J MGP_AKRJ_G0023955
 protein coding gene Chr17:75773316-75814987 (-)
BALB/cJ MGP_BALBcJ_G0023988
 protein coding gene Chr17:74605504-74638060 (-)
C3H/HeJ MGP_C3HHeJ_G0023752
 protein coding gene Chr17:76702097-76735155 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024433
 protein coding gene Chr17:79817584-79857202 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021877
 protein coding gene Chr17:70336801-70370110 (-)
CAST/EiJ MGP_CASTEiJ_G0023232
 protein coding gene Chr17:77200550-77238973 (-)
CBA/J MGP_CBAJ_G0023726
 protein coding gene Chr17:83183626-83223890 (-)
DBA/2J MGP_DBA2J_G0023855
 protein coding gene Chr17:73292743-73325449 (-)
FVB/NJ MGP_FVBNJ_G0023821
 protein coding gene Chr17:72790978-72823191 (-)
LP/J MGP_LPJ_G0023938
 protein coding gene Chr17:77822841-77864691 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023849
 protein coding gene Chr17:82974395-83013298 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024477
 protein coding gene Chr17:76249705-76288117 (-)
PWK/PhJ MGP_PWKPhJ_G0022978
 protein coding gene Chr17:72666192-72701412 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022789
 protein coding gene Chr17:72952138-72985563 (-)
WSB/EiJ MGP_WSBEiJ_G0023299
 protein coding gene Chr17:77117306-77152279 (-)



Homology
more
  • Human Ortholog
    NLRC4, NLR family CARD domain containing 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRC4, NLR family CARD domain containing 4
  • Synonyms
    AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF
  • Links
    NCBI Gene ID: 58484
    neXtProt AC: NX_Q9NPP4
    UniProt: Q9NPP4

  • Chr Location
    2p22.3; chr2:32224449-32265743 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nlrc4 mouse models; 1 with human NLRC4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 9 alleles in 8 genetic backgrounds
    6 phenotypes from multigenic genotypes
    206 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show lack of caspase-1 activation in macrophages infected with Legionella and Salmonella, and enhanced permissivity to Legionella replication. Homozygotes for another null allele fail to show caspase dependent cell death and IL-1 beta secretion upon Salmonella infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 268973 NCBI Gene Model | MGI Sequence Detail 32887 C57BL/6J ±  kb
    transcript NM_001033367 RefSeq | MGI Sequence Detail 3838 C57BL/6  
    polypeptide Q3UP24 UniProt | EBI | MGI Sequence Detail 1024 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 256
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 15
      Phenotypes 206
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:346720 Gul E, et al., Salmonella T3SS-2 virulence enhances gut-luminal colonization by enabling chemotaxis-dependent exploitation of intestinal inflammation. Cell Rep. 2024 Mar 26;43(3):113925
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory