Hfm1 MGI Mouse Gene Detail - MGI:3036246 - HFM1, ATP-dependent DNA helicase homolog

Symbol

Hfm1
Name

HFM1, ATP-dependent DNA helicase homolog
Synonyms

A330009G12Rik, LOC381663, Mer3, Sec63d1

Feature Type

protein coding gene
IDs

MGI:3036246
NCBI Gene: 330149
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:106988058-107074187 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 51.43 cM
Mapping Data

1 experiment

SNPs within 2kb

2102 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3036246	protein coding gene	Chr5:106988058-107074427 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029832	protein coding gene	Chr5:108822327-108911588 (-)
A/J	MGP_AJ_G0029796	protein coding gene	Chr5:104670396-104755773 (-)
AKR/J	MGP_AKRJ_G0029741	protein coding gene	Chr5:108061095-108153612 (-)
BALB/cJ	MGP_BALBcJ_G0029808	protein coding gene	Chr5:105810407-105898232 (-)
C3H/HeJ	MGP_C3HHeJ_G0029530	protein coding gene	Chr5:108508736-108596451 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030262	protein coding gene	Chr5:113336732-113425175 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027496	protein coding gene	Chr5:99738911-99828789 (-)
CAST/EiJ	MGP_CASTEiJ_G0028944	protein coding gene	Chr5:107411332-107503592 (-)
CBA/J	MGP_CBAJ_G0029498	protein coding gene	Chr5:117108939-117211925 (-)
DBA/2J	MGP_DBA2J_G0029644	protein coding gene	Chr5:104812283-104895279 (-)
FVB/NJ	MGP_FVBNJ_G0029601	protein coding gene	Chr5:103535672-103618798 (-)
LP/J	MGP_LPJ_G0029732	protein coding gene	Chr5:109412905-109507897 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029633	protein coding gene	Chr5:122066158-122169168 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030296	protein coding gene	Chr5:107604432-107691222 (-)
PWK/PhJ	MGP_PWKPhJ_G0028657	protein coding gene	Chr5:103602590-103687779 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028495	protein coding gene	Chr5:105102477-105195587 (-)
WSB/EiJ	MGP_WSBEiJ_G0029017	protein coding gene	Chr5:107911860-107998642 (-)

Human Ortholog

HFM1, helicase for meiosis 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HFM1, helicase for meiosis 1
Synonyms

helicase, MER3, POF9, SEC63D1, Si-11, Si-11-6
Links

HGNC:20193

NCBI Gene ID: 164045

neXtProt AC: NX_A2PYH4

UniProt: A2PYH4
Chr Location

1p22.2; chr1:91260766-91408007 (-) GRCh38

MGI Vertebrate Homology

Hfm1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HFM1
Gene Tree

Hfm1

Diseases

1 with human HFM1 associations

				Human Disease	Mouse Models
				primary ovarian insufficiency 9 IDs primary ovarian insufficiency 9 DOID:0080866 OMIM:615724

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Spontaneous

1
Targeted

1
Genomic Mutations

3 involving Hfm1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

85 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Meiosis ais disrupted in homozygotes and bothe sexes are sterile

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hfm1

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All Sequences

96
RefSeq

49
UniProt

9
CCDS

CCDS51582.1

Ensembl

ENSMUSG00000043410 (Evidence)
NCBI Gene

330149

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043410	Ensembl Gene Model \| MGI Sequence Detail	86130	C57BL/6J	± kb
transcript	ENSMUST00000117588	Ensembl \| MGI Sequence Detail	4870	Not Applicable
polypeptide	ENSMUSP00000112590	Ensembl \| MGI Sequence Detail	1434	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000029543 probable ATP-dependent DNA helicase HFM1

(term hierarchy)
EC

3.6.4.12
InterPro Domains

IPR011545 DEAD/DEAH box helicase domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR052247 Meiotic Crossover Helicase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR004179 Sec63 domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 4

cDNA 4

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MGI:2685892

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:358355 Rezaei M, et al., Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles. J Clin Invest. 2024 Nov 15;134(22)

TSS for Hfm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1579	Chr5:107074423-107074433 (-)	-241 bp
Tssr52356	Chr5:107074111-107074150 (-)	56 bp
Tssr52355	Chr5:107073705-107073730 (-)	469 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24