Lix1l MGI Mouse Gene Detail - MGI:3036267

Symbol

Lix1l
Name

Lix1-like
Synonyms

D130027M04Rik

Feature Type

protein coding gene
IDs

MGI:3036267
NCBI Gene: 280411
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:96508449-96532668 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 41.93 cM
Mapping Data

1 experiment

SNPs within 2kb

532 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3036267	protein coding gene	Chr3:96508449-96533487 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027623	protein coding gene	Chr3:97481475-97510335 (+)
A/J	MGP_AJ_G0027585	protein coding gene	Chr3:94366069-94392235 (+)
AKR/J	MGP_AKRJ_G0027552	protein coding gene	Chr3:96587345-96617157 (+)
BALB/cJ	MGP_BALBcJ_G0027595	protein coding gene	Chr3:94175380-94201427 (+)
C3H/HeJ	MGP_C3HHeJ_G0027327	protein coding gene	Chr3:96897506-96924530 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028041	protein coding gene	Chr3:101036207-101066845 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025382	protein coding gene	Chr3:90644344-90669280 (+)
CAST/EiJ	MGP_CASTEiJ_G0026782	protein coding gene	Chr3:96145782-96176225 (+)
CBA/J	MGP_CBAJ_G0027302	protein coding gene	Chr3:104732463-104763661 (+)
DBA/2J	MGP_DBA2J_G0027445	protein coding gene	Chr3:93696857-93722965 (+)
FVB/NJ	MGP_FVBNJ_G0027414	protein coding gene	Chr3:91706982-91733309 (+)
LP/J	MGP_LPJ_G0027550	protein coding gene	Chr3:98766369-98796082 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027440	protein coding gene	Chr3:110803879-110846269 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028095	protein coding gene	Chr3:96203913-96233679 (+)
PWK/PhJ	MGP_PWKPhJ_G0026507	protein coding gene	Chr3:93531012-93557423 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026329	protein coding gene	Chr3:94506410-94533668 (+)
WSB/EiJ	MGP_WSBEiJ_G0026860	protein coding gene	Chr3:96653713-96679936 (+)

Human Ortholog

LIX1L, limb and CNS expressed 1 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LIX1L, limb and CNS expressed 1 like
Links

HGNC:28715

NCBI Gene ID: 128077

neXtProt AC: NX_Q8IVB5

UniProt: Q8IVB5
Chr Location

1q21.1; chr1:145933423-145958017 (-) GRCh38

MGI Vertebrate Homology

Lix1l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LIX1L
Gene Tree

Lix1l

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References

1 with disease annotations

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Phenotype Summary

13 phenotype references

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Lix1l
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

11 strains or lines available

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All GO Annotations

2
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

81
cDNA Data

29
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lix1l

ZFIN lix1l

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS51004.1

Ensembl

ENSMUSG00000049288 (Evidence)
NCBI Gene

280411

			Length	Strain/Species	Flank
genomic	280411	NCBI Gene Model \| MGI Sequence Detail	24220	C57BL/6J	± kb
transcript	NM_001163170	RefSeq \| MGI Sequence Detail	2509	C57BL/6
polypeptide	Q8BQ89	UniProt \| EBI \| MGI Sequence Detail	337	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009845 LIX1-like protein

(term hierarchy)
InterPro Domains

IPR051436 Autophagy-related EPG5

IPR029270 Limb expression 1

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All nucleic 29

cDNA 29

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 4

Diseases 1

Gene Ontology 1

Phenotypes 13
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lix1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30740	Chr3:96508400-96508455 (+)	-21 bp
Tssr30741	Chr3:96525913-96525944 (+)	17,480 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24