Kcnt2 MGI Mouse Gene Detail - MGI:3036273 - potassium channel, subfamily T, member 2

Symbol

Kcnt2
Name

potassium channel, subfamily T, member 2
Synonyms

E330038N15Rik

Feature Type

protein coding gene
IDs

MGI:3036273
NCBI Gene: 240776
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:140173896-140539805 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 61.62 cM
Mapping Data

1 experiment

SNPs within 2kb

10090 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3036273	protein coding gene	Chr1:140173373-140541783 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016559	protein coding gene	Chr1:144390111-144788000 (+)
A/J	MGP_AJ_G0016542	protein coding gene	Chr1:138767019-139137486 (+)
AKR/J	MGP_AKRJ_G0016507	protein coding gene	Chr1:142987782-143363086 (+)
BALB/cJ	MGP_BALBcJ_G0016502	protein coding gene	Chr1:139138648-139510013 (+)
C3H/HeJ	MGP_C3HHeJ_G0016327	protein coding gene	Chr1:143121437-143501863 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016963	protein coding gene	Chr1:149448746-149849173 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014672	protein coding gene	Chr1:131849874-132200655 (+)
CAST/EiJ	MGP_CASTEiJ_G0015906	protein coding gene	Chr1:142477353-142873682 (+)
CBA/J	MGP_CBAJ_G0016301	protein coding gene	Chr1:154539573-154958048 (+)
DBA/2J	MGP_DBA2J_G0016407	protein coding gene	Chr1:137781002-138158948 (+)
FVB/NJ	MGP_FVBNJ_G0016405	protein coding gene	Chr1:136406198-136772356 (+)
LP/J	MGP_LPJ_G0016478	protein coding gene	Chr1:145539173-145928532 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016431	protein coding gene	Chr1:160348187-160844733 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016999	protein coding gene	Chr1:142722470-143097363 (+)
PWK/PhJ	MGP_PWKPhJ_G0015692	protein coding gene	Chr1:136747059-137119394 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015479	protein coding gene	Chr1:141513964-141896928 (+)
WSB/EiJ	MGP_WSBEiJ_G0015969	protein coding gene	Chr1:142722796-143110872 (+)

Human Ortholog

KCNT2, potassium sodium-activated channel subfamily T member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNT2, potassium sodium-activated channel subfamily T member 2
Synonyms

DEE57, EIEE57, KCa4.2, KNa1.2, SLICK, SLO2.1
Links

HGNC:18866

NCBI Gene ID: 343450

neXtProt AC: NX_Q6UVM3

UniProt: Q6UVM3
Chr Location

1q31.3

MGI Vertebrate Homology

Kcnt2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KCNT2
Gene Tree

Kcnt2

Diseases

1 with human KCNT2 associations

				Human Disease	Mouse Models
				developmental and epileptic encephalopathy 57 IDs developmental and epileptic encephalopathy 57 DOID:0080284 OMIM:617771

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

13
Targeted

4
Genomic Mutations

2 involving Kcnt2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

111 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele are viable with normal pain and itch responses.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

22
cDNA Data

2
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnt2

ZFIN kcnt2a

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All Sequences

81
RefSeq

42
UniProt

5
CCDS

CCDS48389.1

Ensembl

ENSMUSG00000052726 (Evidence)
NCBI Gene

240776

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052726	Ensembl Gene Model \| MGI Sequence Detail	365910	C57BL/6J	± kb
transcript	ENSMUST00000120796	Ensembl \| MGI Sequence Detail	3540	Not Applicable
polypeptide	ENSMUSP00000113333	Ensembl \| MGI Sequence Detail	1135	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR003929 Calcium-activated potassium channel BK, alpha subunit

IPR047871 Calcium-activated potassium channel slowpoke-like

IPR036291 NAD(P)-binding domain superfamily

IPR013099 Potassium channel domain

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All nucleic 2

cDNA 2

Microarray probesets 2

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 17
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kcnt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9180	Chr1:140173448-140173470 (+)	-437 bp
Tssr237	Chr1:140173653-140173660 (+)	-239 bp
Tssr9181	Chr1:140173750-140173782 (+)	-130 bp
Tssr9182	Chr1:140173787-140173799 (+)	-103 bp
Tssr9183	Chr1:140309269-140309272 (+)	135,375 bp
Tssr9184	Chr1:140499811-140499816 (+)	325,918 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24