Tg(Vav-BCL2)69Jad
Transgene Detail

Summary

• Symbol: Tg(Vav-BCL2)69Jad
• Name: transgene insertion 69, Jerry M Adams
• MGI ID: MGI:2429387
• Synonyms: Bcl2⁰, hBcl-2 Tg, Tg(Vav-BCL2)1Jad, Vav2-hBcl-2, vav-bcl-2, vav-Bcl2, vav-bcl-2-69
• Transgene: Tg(Vav-BCL2)69Jad Location: unknown
• Alliance: Tg(Vav-BCL2)69Jad page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Vav-BCL2)69Jad expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

• Mutation details: Overexpression of human BCL2 cDNA was driven by the mouse Vav promoter, which drives expression predominantly in nucleated cells of hematopoietic tissue. (J:59085)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available

References

• Original: J:59085 Ogilvy S, et al., Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14943-8
• All: 109 reference(s)