Tg(WTbeta2)4Wjk
Transgene Detail

Summary

• Symbol: Tg(WTbeta2)4Wjk
• Name: transgene insertion 4, Walter Koch
• MGI ID: MGI:3037368
• Synonyms: TG4, Tg(Myh6-ADRB2)4Wjk
• Transgene: Tg(WTbeta2)4Wjk Location: unknown
• Alliance: Tg(WTbeta2)4Wjk page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(WTbeta2)4Wjk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ADRB2 (154)

  Adrb2

  (MGI:87938)

• Mutation details: The transgene consists of the human beta-2 adrenergic receptor (ADRB2), an SV40 intron/polyA sequence, and the murine myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) promoter which directs cardiac-specific overexpression of ADRB2. Transgene expression is detected in cardiac myocytes at levels 200 times greater than in human cardiac tissue. (J:17862)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:17862 Milano CA, et al., Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor [see comments]. Science. 1994 Apr 22;264(5158):582-6
• All: 23 reference(s)