Tg(CAMalpha1b)7Wjk
Transgene Detail

Summary

• Symbol: Tg(CAMalpha1b)7Wjk
• Name: transgene insertion 7, Walter Koch
• MGI ID: MGI:1858099
• Synonyms: CAM7, (CAM)alpha1B-AR, CAMalpha1B-AR
• Transgene: Tg(CAMalpha1b)7Wjk Location: unknown
• Alliance: Tg(CAMalpha1b)7Wjk page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAMalpha1b)7Wjk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  hamster	Adra1b (101843941)

• Mutation details: Sequence encoding hamster adrenergic receptor alpha 1b (ADRA1B), containing 3 missense mutations (R288K, K290H, A293L) to make it constitutively active, was adjoined to the mouse myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) promoter. Cardiac-specific expression of the mutant ADRA1B was indicated by radio ligand binding assay to be approximately 3-fold higher than that of the endogenous Adra1b. In addition to line 7 (CAM7), lines 21 (CAM21) and 56 (CAM56) were also generated. They also overexpress by approximately 3-fold. (J:82721)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1  Disease Model	Tg(CAMalpha1b)7Wjk/?	Not Specified

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
cardiovascular system	√
cardiovascular system phenotype	N
abnormal myocardium layer morphology	√
myocardial fiber disarray	√
abnormal heart ventricle shape	√
increased heart weight	√
cardiac hypertrophy	√
heart right ventricle hypertrophy	√
increased heart left ventricle size	√
dilated heart	√
dilated cardiomyopathy	√
decreased heart left ventricle muscle contractility	√
abnormal heart echocardiography feature	√
congestive heart failure	√
growth/size/body	√
increased heart weight	√
cardiac hypertrophy	√
heart right ventricle hypertrophy	√
homeostasis/metabolism	√
abnormal atrial thrombosis	√
generalized edema	√
mortality/aging	√
premature death	√
muscle	√
abnormal myocardium layer morphology	√
myocardial fiber disarray	√
heart right ventricle hypertrophy	√
dilated cardiomyopathy	√
decreased heart left ventricle muscle contractility	√
respiratory system	√
respiratory distress	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg1
dilated cardiomyopathy IDs dilated cardiomyopathy       DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193 Close	√

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:82721 Milano CA, et al., Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):10109-13
• All: 4 reference(s)