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Kcna10 Gene Detail
Summary
  • Symbol
    Kcna10
  • Name
    potassium voltage-gated channel, shaker-related subfamily, member 10
  • Synonyms
    Kcna8, Kv1.8
  • Feature Type
    protein coding gene
  • IDs
    MGI:3037820
    NCBI Gene: 242151
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107090459-107103037 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.64 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    433 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3037820
 protein coding gene Chr3:107090372-107103037 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027741
 protein coding gene Chr3:108658828-108673731 (+)
A/J MGP_AJ_G0027701
 protein coding gene Chr3:105215178-105227768 (+)
AKR/J MGP_AKRJ_G0027666
 protein coding gene Chr3:107787048-107799655 (+)
BALB/cJ MGP_BALBcJ_G0027713
 protein coding gene Chr3:104911096-104924480 (+)
C3H/HeJ MGP_C3HHeJ_G0027443
 protein coding gene Chr3:108127852-108140490 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028157
 protein coding gene Chr3:112738883-112752491 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025495
 protein coding gene Chr3:101368792-101384292 (+)
CAST/EiJ MGP_CASTEiJ_G0026899
 protein coding gene Chr3:107491643-107506477 (+)
CBA/J MGP_CBAJ_G0027418
 protein coding gene Chr3:116548151-116560702 (+)
DBA/2J MGP_DBA2J_G0027560
 protein coding gene Chr3:104416676-104429271 (+)
FVB/NJ MGP_FVBNJ_G0027528
 protein coding gene Chr3:102299894-102312954 (+)
LP/J MGP_LPJ_G0027667
 protein coding gene Chr3:110075660-110090445 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027558
 protein coding gene Chr3:122669490-122685020 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028212
 protein coding gene Chr3:107370431-107385776 (+)
PWK/PhJ MGP_PWKPhJ_G0026625
 protein coding gene Chr3:104140813-104154381 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026445
 protein coding gene Chr3:105510231-105522979 (+)
WSB/EiJ MGP_WSBEiJ_G0026979
 protein coding gene Chr3:107900009-107912517 (+)



Homology
more
  • Human Ortholog
    KCNA10, potassium voltage-gated channel subfamily A member 10
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNA10, potassium voltage-gated channel subfamily A member 10
  • Synonyms
    Kcn1, Kv1.8
  • Links
    NCBI Gene ID: 3744
    neXtProt AC: NX_Q16322
    UniProt: Q16322

  • Chr Location
    1p13.3; chr1:110517217-110519175 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kcna10 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit significant vestibular and mild hearing dysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    40
  • cDNA Data
    6
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242151 NCBI Gene Model | MGI Sequence Detail 12579 C57BL/6J ±  kb
    transcript NM_001081140 RefSeq | MGI Sequence Detail 1826 Not Specified  
    polypeptide B2RQA1 UniProt | EBI | MGI Sequence Detail 511 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 4
      cDNA 6
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-11569, MGI:96665
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:17629 Lock LF, et al., Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome. Genomics. 1994 Apr;20(3):354-62
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory