Tg(LPV-TAg121)2Tvd
Transgene Detail

Summary

• Symbol: Tg(LPV-TAg121)2Tvd
• Name: transgene insertion 2, Terry van Dyke
• MGI ID: MGI:2445949
• Synonyms: dl1137, LST1137, T121, Tg(LPV-SV40T-T121)1Tvd, TgT(121), TgT121
• Transgene: Tg(LPV-TAg121)2Tvd Location: unknown
• Alliance: Tg(LPV-TAg121)2Tvd page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene consists of a lymphotrophic papovavirus (LPV) enhancer/early promoter and a mutant SV40 T antigen sequence truncated after amino acid 121 followed by 11 missense residues. The resulting protein includes the RB1-binding region but lacks the small t antigen and TRP53-binding region. Regulatory sequences direct expression of the transgene in B- and T-lymphocytes and choroid plexus epithelium. (J:89094)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(LPV-TAg121)2Tvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

All transgenic mice examined at ~26 weeks of age had choroid plexus tumors. These tumors grew more slowly than similar tumors seen in transgenic mice carrying the wild-type T antigen (Tg(LPV-Tag)1Tvd).

References

• Original: J:72121 Saenz Robles MT, et al., Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen. Mol Cell Biol. 1994 Apr;14(4):2686-98
• All: 13 reference(s)