Tg(GFAP-TAg121)1Tvd
Transgene Detail

Summary

• Symbol: Tg(GFAP-TAg121)1Tvd
• Name: transgene insertion 1, Terry Van Dyke
• MGI ID: MGI:2445447
• Synonyms: G(deltaZ)T121, GdeltaZT121, TgG(deltaZ)T121, Tg(GFAP-SV40T)2.1Tvd, Tg(GFAP-T121)2.1Tvd
• Transgene: Tg(GFAP-TAg121)1Tvd Location: unknown
• Alliance: Tg(GFAP-TAg121)1Tvd page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This allele was derived from mating Tg(GFAP-lacZ-TAg121)92Tvd animals to mice carrying a cre transgene (Tg(ACTB-cre)2Mrt). As a result the intervening floxed lacZ cassette was removed, leaving a single loxP site and allowing transcription from the mutant SV40 T antigen sequence. The mutant SV40 T antigen 121 contains a deletion for the small t antigen-specific splice signal and a deletion that results in truncation of the large T antigen at amino acid 121. The mutant antigen binds RB1/RBL1/RBL2 but not TRP53. Immunohistochemical analysis of progeny showed diffuse expression of this transgene throughout the brain. (J:77132)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(GFAP-TAg121)1Tvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:77132 Xiao A, et al., Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell. 2002 Mar;1(2):157-68
• All: 5 reference(s)