Tg(MMTV-TGFBR2)7Hlm
Transgene Detail

Summary

• Symbol: Tg(MMTV-TGFBR2)7Hlm
• Name: transgene insertion 7, Harold L Moses
• MGI ID: MGI:2429406
• Synonyms: MMTV-DNIIR-7, TGF-betaRIIDN
• Transgene: Tg(MMTV-TGFBR2)7Hlm Location: unknown
• Alliance: Tg(MMTV-TGFBR2)7Hlm page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-TGFBR2)7Hlm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TGFB2 (7042)

  Tgfb2

  (MGI:98726)

• Mutation details: A human cDNA encoding a carboxy-terminally truncated TGFBR2 was adjoined to an MMTV regulatory region. While the encoded receptor contains the complete extracellular and transmembrane domains and is therefore capable of ligand binding and and interacting with type 1 receptors, it lacks the kinase domain. Expression was driven in mammary epithelial cells by the MMTV LTR promoter/enhancer. Transgenic expression was verified by Northern blot analysis. (J:46432)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-TGFBR2)7Hlm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:46432 Gorska AE, et al., Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice. Cell Growth Differ. 1998 Mar;9(3):229-38
• All: 5 reference(s)