Tg(Alb1-Ren)2Unc
Transgene Detail

Summary

• Symbol: Tg(Alb1-Ren)2Unc
• Name: transgene insertion 2, University of North Carolina
• MGI ID: MGI:3039271
• Synonyms: RenTgMK, Tg(Alb1-Ren)1Smi
• Transgene: Tg(Alb1-Ren)2Unc Location: unknown
• Alliance: Tg(Alb1-Ren)2Unc page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:89252
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb1-Ren)2Unc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ren1 (MGI:97898)

• Mutation details: A single copy of a transgene consisting of a liver specific albumin promoter, a 20 bp insert in the 5' UTR to increase length, a synthetic mouse renin cDNA, and a rabbit beta-globin 3' UTR was inserted into the apolipoprotein locus between the Apoa1 and Apoc3 genes. (J:89252)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
cx1	Adm^tm1Unc/Adm^+ Tg(Alb1-Ren)2Unc/?	129S6/SvEvTac-Adm^tm1Unc Tg(Alb1-Ren)2Unc
tg2	Tg(Alb1-Ren)2Unc/0	involves: 129S6/SvEvTac * C57BL/6
tg3	Tg(Alb1-Ren)2Unc/?	129S6/SvEvTac-Tg(Alb1-Ren)2Unc

Phenotypes:

Affected Systems	cx1	tg2	tg3
show or hide all annotated terms
behavior/neurological		√
polydipsia		√
cardiovascular system	√	√	√
increased myocardial fiber size	√
cardiac hypertrophy	√	√
decreased heart rate		√
increased systemic arterial blood pressure	√		√
hypertension		√
growth/size/body	√	√
cardiac hypertrophy	√	√
homeostasis/metabolism		√
increased circulating creatinine level		√
decreased urine osmolality		√
albuminuria		√
immune system		√
kidney inflammation		√
mortality/aging		√
premature death		√
muscle	√
increased myocardial fiber size	√
renal/urinary system	√	√
decreased urine osmolality		√
albuminuria		√
kidney inflammation		√
glomerulosclerosis	√
renal cast	√
renal fibrosis	√
polyuria		√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:89252 Caron KM, et al., A genetically clamped renin transgene for the induction of hypertension. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8248-52
• All: 10 reference(s)