Mtss2 MGI Mouse Gene Detail - MGI:3039591 - MTSS I-BAR domain containing 2

Symbol

Mtss2
Name

MTSS I-BAR domain containing 2
Synonyms

ABBA, Mtss1l

Feature Type

protein coding gene
IDs

MGI:3039591
NCBI Gene: 244654
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr8:111448108-111468032 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 57.66 cM
Mapping Data

1 experiment

SNPs within 2kb

392 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3039591	protein coding gene	Chr8:111447718-111468032 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034126	protein coding gene	Chr8:113400548-113423327 (+)
A/J	MGP_AJ_G0034105	protein coding gene	Chr8:108808552-108829068 (+)
AKR/J	MGP_AKRJ_G0034032	protein coding gene	Chr8:111999832-112021327 (+)
BALB/cJ	MGP_BALBcJ_G0034099	protein coding gene	Chr8:109000859-109021147 (+)
C3H/HeJ	MGP_C3HHeJ_G0033810	protein coding gene	Chr8:112713303-112735578 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034619	protein coding gene	Chr8:117396774-117418350 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031561	protein coding gene	Chr8:101807024-101827109 (+)
CAST/EiJ	MGP_CASTEiJ_G0033137	protein coding gene	Chr8:112323971-112348215 (+)
CBA/J	MGP_CBAJ_G0033784	protein coding gene	Chr8:121364172-121384000 (+)
DBA/2J	MGP_DBA2J_G0033939	protein coding gene	Chr8:108114234-108134642 (+)
FVB/NJ	MGP_FVBNJ_G0033883	protein coding gene	Chr8:107071475-107092506 (+)
LP/J	MGP_LPJ_G0034029	protein coding gene	Chr8:113592432-113614810 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033929	protein coding gene	Chr8:124297271-124318062 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034638	protein coding gene	Chr8:111968522-111988787 (+)
PWK/PhJ	MGP_PWKPhJ_G0032840	protein coding gene	Chr8:107692073-107712385 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032679	protein coding gene	Chr8:110653679-110673340 (+)
WSB/EiJ	MGP_WSBEiJ_G0033253	protein coding gene	Chr8:112654113-112675146 (+)

Human Ortholog

MTSS2, MTSS I-BAR domain containing 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTSS2, MTSS I-BAR domain containing 2
Synonyms

ABBA, ABBA-1, ABBA1, IDDOF, MTSS1L
Links

HGNC:25094

NCBI Gene ID: 92154

neXtProt AC: NX_Q765P7

UniProt: Q765P7
Chr Location

16q22.1; chr16:70661204-70686053 (-) GRCh38

MGI Vertebrate Homology

Mtss2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MTSS2
Gene Tree

Mtss2

Diseases

1 with human MTSS2 associations

				Human Disease	Mouse Models
				intellectual developmental disorder with ocular anomalies and distinctive facial features IDs intellectual developmental disorder with ocular anomalies and distinctive facial features DOID:0081301 OMIM:620086

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

24
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

943
Tissues

60
cDNA Data

59
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mtss2

ZFIN mtss1la

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All Sequences

79
RefSeq

36
UniProt

4
CCDS

CCDS22664.1, CCDS80930.1

Ensembl

ENSMUSG00000033763 (Evidence)
NCBI Gene

244654

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033763	Ensembl Gene Model \| MGI Sequence Detail	19925	C57BL/6J	± kb
transcript	ENSMUST00000052457	Ensembl \| MGI Sequence Detail	4717	Not Applicable
polypeptide	ENSMUSP00000050211	Ensembl \| MGI Sequence Detail	715	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010752 protein MTSS 2

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR030127 I-BAR domain containing protein MTSS1/MTSS2

IPR013606 IMD/I-BAR domain
GlyGen

Q6P9S0 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 60

cDNA 59

Other 1

Microarray probesets 2

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MGI:6286288

Summaries

All 34

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 8
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mtss2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79423	Chr8:111448054-111448076 (+)	-43 bp
Tssr79424	Chr8:111448083-111448088 (+)	-22 bp
Tssr79425	Chr8:111448094-111448118 (+)	-2 bp
Tssr79426	Chr8:111448128-111448136 (+)	24 bp
Tssr79427	Chr8:111448287-111448356 (+)	214 bp
Tssr79428	Chr8:111453742-111453763 (+)	5,645 bp
Tssr79429	Chr8:111455464-111455486 (+)	7,367 bp
Tssr79430	Chr8:111456687-111456708 (+)	8,590 bp
Tssr79431	Chr8:111458753-111458766 (+)	10,652 bp
Tssr79432	Chr8:111464565-111464580 (+)	16,465 bp
Tssr2686	Chr8:111465191-111465209 (+)	17,092 bp
Tssr79433	Chr8:111467557-111467565 (+)	19,453 bp
Tssr79434	Chr8:111467689-111467703 (+)	19,588 bp
Tssr79435	Chr8:111467818-111467837 (+)	19,720 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24