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A2ml1 Gene Detail
Summary
  • Symbol
    A2ml1
  • Name
    alpha-2-macroglobulin like 1
  • Synonyms
    BC048546, Ovos2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039594
    NCBI Gene: 232400
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128516784-128558571 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1616 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039594
 protein coding gene Chr6:128516784-128577014 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031329
 protein coding gene Chr6:132164654-132208634 (-)
A/J MGP_AJ_G0031300
 protein coding gene Chr6:127085008-127128043 (-)
AKR/J MGP_AKRJ_G0031228
 protein coding gene Chr6:130509761-130553137 (-)
BALB/cJ MGP_BALBcJ_G0031307
 protein coding gene Chr6:126660260-126707565 (-)
C3H/HeJ MGP_C3HHeJ_G0031031
 protein coding gene Chr6:130660705-130704752 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031766
 protein coding gene Chr6:135599963-135643309 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028912
 protein coding gene Chr6:124295931-124337554 (-)
CAST/EiJ MGP_CASTEiJ_G0030412
 protein coding gene Chr6:130956449-130999428 (-)
CBA/J MGP_CBAJ_G0030992
 protein coding gene Chr6:140844324-140896033 (-)
DBA/2J MGP_DBA2J_G0031148
 protein coding gene Chr6:125983139-126026476 (-)
FVB/NJ MGP_FVBNJ_G0031098
 protein coding gene Chr6:124910947-124953536 (-)
LP/J MGP_LPJ_G0031228
 protein coding gene Chr6:132278035-132322090 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031136
 protein coding gene Chr6:144657710-144706053 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031799
 protein coding gene Chr6:130520437-130570319 (-)
PWK/PhJ MGP_PWKPhJ_G0030127
 protein coding gene Chr6:124282632-124329636 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029956
 protein coding gene Chr6:128656222-128697820 (-)
WSB/EiJ MGP_WSBEiJ_G0030497
 protein coding gene Chr6:130922663-130968934 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    15
  • cDNA Data
    180
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047228 Ensembl Gene Model | MGI Sequence Detail 41788 C57BL/6J ±  kb
    transcript ENSMUST00000060574 Ensembl | MGI Sequence Detail 4695 Not Applicable  
    polypeptide ENSMUSP00000059426 Ensembl | MGI Sequence Detail 1456 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 181
      cDNA 180
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:351592 Elling CL, et al., The A2ml1-Knockout mouse as an animal model for non-syndromic otitis media. Int J Pediatr Otorhinolaryngol. 2024 Jun;181:111980
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory