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Slc17a8 Gene Detail
Summary
  • Symbol
    Slc17a8
  • Name
    solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
  • Synonyms
    Vglut3, Vgt3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039629
    NCBI Gene: 216227
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:89409882-89457111 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 44.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1736 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039629
 protein coding gene Chr10:89409882-89457115 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017637
 protein coding gene Chr10:90759094-90813645 (-)
A/J MGP_AJ_G0017616
 protein coding gene Chr10:87651804-87711507 (-)
AKR/J MGP_AKRJ_G0017574
 protein coding gene Chr10:90143198-90194517 (-)
BALB/cJ MGP_BALBcJ_G0017579
 protein coding gene Chr10:87920972-87971490 (-)
C3H/HeJ MGP_C3HHeJ_G0017402
 protein coding gene Chr10:90160555-90208944 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018036
 protein coding gene Chr10:93794576-93851307 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015718
 protein coding gene Chr10:83371902-83419586 (-)
CAST/EiJ MGP_CASTEiJ_G0016967
 protein coding gene Chr10:90071274-90125539 (-)
CBA/J MGP_CBAJ_G0017371
 protein coding gene Chr10:97666319-97722980 (-)
DBA/2J MGP_DBA2J_G0017477
 protein coding gene Chr10:86785298-86829953 (-)
FVB/NJ MGP_FVBNJ_G0017469
 protein coding gene Chr10:85988734-86052297 (-)
LP/J MGP_LPJ_G0017551
 protein coding gene Chr10:91403207-91454793 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017500
 protein coding gene Chr10:99151155-99204363 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018073
 protein coding gene Chr10:90028928-90087546 (-)
PWK/PhJ MGP_PWKPhJ_G0016748
 protein coding gene Chr10:86808697-86858755 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016536
 protein coding gene Chr10:88796427-88842596 (-)
WSB/EiJ MGP_WSBEiJ_G0017026
 protein coding gene Chr10:90027789-90076568 (-)



Homology
more
  • Human Ortholog
    SLC17A8, solute carrier family 17 member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC17A8, solute carrier family 17 member 8
  • Synonyms
    DFNA25, VGLUT3
  • Links
    NCBI Gene ID: 246213
    neXtProt AC: NX_Q8NDX2
    UniProt: Q8NDX2

  • Chr Location
    12q23.1; chr12:100357074-100422055 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc17a8 mouse models; 1 with human SLC17A8 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit sensorineural hearing loss, cochlear ganglion degeneration, decreased synaptic glutamate release, and nonconvulsive seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    38
  • cDNA Data
    7
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 216227 NCBI Gene Model | MGI Sequence Detail 47230 C57BL/6J ±  kb
    transcript NM_182959 RefSeq | MGI Sequence Detail 4452 C57BL/6  
    polypeptide Q8BFU8 UniProt | EBI | MGI Sequence Detail 601 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000014964 vesicular glutamate transporter 3
      (term hierarchy)
    • InterPro Domains
      IPR011701 Major facilitator superfamily
      IPR020846 Major facilitator superfamily domain
      IPR050382 Major Facilitator Superfamily Sodium/Anion Cotransporter
      IPR036259 MFS transporter superfamily
    • GlyGen
      Q8BFU8 3 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 170
      Developmental Gene Expression 33
      Diseases 1
      Gene Ontology 14
      Phenotypes 100
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:359088 Stinson HE, et al., Median raphe glutamatergic neuron-mediated enhancement of GABAergic transmission and suppression of long-term potentiation in the hippocampus. Heliyon. 2024 Oct 15;10(19):e38192
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory