Tg(Wap-HRAS)69Lln
Transgene Detail

Summary

• Symbol: Tg(Wap-HRAS)69Lln
• Name: transgene insertion 69, Loretta L Nielsen
• MGI ID: MGI:3039648
• Synonyms: HRAS, Tg(Wap-HRAS)69Lin, Tg(WapHRAS)69Lin
• Transgene: Tg(Wap-HRAS)69Lln Location: unknown Genetic Position: ChrY, Syntenic
• Alliance: Tg(Wap-HRAS)69Lln page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Wap-HRAS)69Lln expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HRAS (3265)

  Hras	(MGI:96224)

• Mutation details: This transgene contains the murine whey acidic protein promoter and an allele of the human Harvey rat sarcoma viral oncogene gene homolog that contains a point mutation in codon 12. The transgene integrated into the Y chromosome (SJL). (J:72262)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Wap-HRAS)69Lln

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:72262 Andres AC, et al., Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1299-303
• All: 8 reference(s)