Tg(OMP-SV40T)13Bse
Transgene Detail

Summary

• Symbol: Tg(OMP-SV40T)13Bse
• Name: transgene insertion 13, Bo Servenius
• MGI ID: MGI:3040254
• Transgene: Tg(OMP-SV40T)13Bse Location: unknown
• Alliance: Tg(OMP-SV40T)13Bse page

Transgene origin

• Strain of Origin: (SJL x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the mouse olfactory marker protein promoter and the wild-type alleles of the SV40 large (Tag) and small (tag) T antigen genes.

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
tg1  Disease Model	Tg(OMP-SV40T)13Bse/0	involves: C57BL/6 * SJL

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
endocrine/exocrine glands	√
increased adrenal gland tumor incidence	√
immune system	√
abnormal immune tolerance	√
mortality/aging	√
decreased tumor-free survival time	√
neoplasm	√
increased adrenal gland tumor incidence	√
increased metastatic potential	√
increased neuroblastoma incidence	√
nervous system	√
increased neuroblastoma incidence	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg1
neuroblastoma IDs neuroblastoma       DOID:769 EFO:0000621 MESH:D009447 NCI:C3270 ORDO:635 UMLS_CUI:C0027819 Close	√

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(OMP-SV40T)13Bse

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Additional lines were produced (see also lines 7, 37, and 50); mice carrying this transgene develop neuroblast neuroblastomas.

References

• Original: J:54269 Servenius B, et al., Metastasizing neuroblastomas in mice transgenic for simian virus 40 large T (SV40T) under the olfactory marker protein gene promoter. Cancer Res. 1994 Oct 1;54(19):5198-205
• All: 1 reference(s)