Tg(RIR-Tag)87Dh
Transgene Detail

Summary

• Symbol: Tg(RIR-Tag)87Dh
• Name: transgene insertion 87, Douglas Hanahan
• MGI ID: MGI:3040264
• Transgene: Tg(RIR-Tag)87Dh Location: unknown
• Alliance: Tg(RIR-Tag)87Dh page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the rat insulin 2 promoter and the wild-type allele of the SV40 large T antigen (Tag) gene. (J:50695)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1  Disease Model	Tg(RIR-Tag)87Dh/0	involves: C57BL/6J * DBA/2J

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
endocrine/exocrine glands	√
abnormal pancreatic islet morphology	√
decreased pancreatic alpha cell number	√
increased pancreatic beta cell number	√
decreased pancreatic delta cell number	√
increased pancreas tumor incidence	√
homeostasis/metabolism	√
hypoglycemia	√
mortality/aging	√
premature death	√
neoplasm	√
increased pancreas tumor incidence	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg1
pancreatic carcinoma IDs pancreatic carcinoma       DOID:4905 EFO:0002618 NCI:C3850 OMIM:260350 UMLS_CUI:C0235974 Close	√

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Line 87, the only line produced, carries a single copy of the transgene. Transgenic mice die prematurely at 9-12 weeks of age.

References

• Original: J:50695 Hanahan D, Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature. 1985 May 9-15;315(6015):115-22
• All: 1 reference(s)