Tg(WapTAg)1Knw
Transgene Detail

Summary

• Symbol: Tg(WapTAg)1Knw
• Name: transgene insertion 1, Barbara B Knowles
• MGI ID: MGI:3040314
• Synonyms: WAPTag 1
• Transgene: Tg(WapTAg)1Knw Location: unknown
• Alliance: Tg(WapTAg)1Knw page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains the mouse Wap (whey acidic protein) promoter and the wild-type allele of the SV40 large T antigen (Tag) gene. (J:53175)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1  Disease Model	Tg(WapTAg)1Knw/0	C57BL/6J-Tg(WapTAg)1Knw/J

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
endocrine/exocrine glands	√
increased mammary adenocarcinoma incidence	√
integument	√
increased mammary adenocarcinoma incidence	√
neoplasm	√
increased mammary adenocarcinoma incidence	√
increased sarcoma incidence	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg1
breast cancer IDs breast cancer       DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142 Close	√

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(WapTAg)1Knw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:53175 Husler MR, et al., Lactation-induced WAP-SV40 Tag transgene expression in C57BL/6J mice leads to mammary carcinoma. Transgenic Res. 1998 Jul;7(4):253-63
• All: 6 reference(s)