Lsm14b MGI Mouse Gene Detail - MGI:3040677

Symbol

Lsm14b
Name

LSM family member 14B

Feature Type

protein coding gene
IDs

MGI:3040677
NCBI Gene: 241846
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:179666780-179677258 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 102.54 cM
Mapping Data

1 experiment

SNPs within 2kb

244 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3040677	protein coding gene	Chr2:179666770-179677258 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026982	protein coding gene	Chr2:186522094-186532554 (+)
A/J	MGP_AJ_G0026948	protein coding gene	Chr2:178861568-178872030 (+)
AKR/J	MGP_AKRJ_G0026918	protein coding gene	Chr2:184212881-184223378 (+)
BALB/cJ	MGP_BALBcJ_G0026957	protein coding gene	Chr2:179323699-179334163 (+)
C3H/HeJ	MGP_C3HHeJ_G0026698	protein coding gene	Chr2:184570766-184581247 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027403	protein coding gene	Chr2:191915289-191925781 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024770	protein coding gene	Chr2:169553858-169564083 (+)
CAST/EiJ	MGP_CASTEiJ_G0026157	protein coding gene	Chr2:182808659-182822469 (+)
CBA/J	MGP_CBAJ_G0026675	protein coding gene	Chr2:198868350-198878806 (+)
DBA/2J	MGP_DBA2J_G0026813	protein coding gene	Chr2:177956828-177967301 (+)
FVB/NJ	MGP_FVBNJ_G0026779	protein coding gene	Chr2:176558556-176569015 (+)
LP/J	MGP_LPJ_G0026914	protein coding gene	Chr2:186510340-186520866 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026798	protein coding gene	Chr2:201524251-201534713 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027462	protein coding gene	Chr2:184176244-184186723 (+)
PWK/PhJ	MGP_PWKPhJ_G0025893	protein coding gene	Chr2:175467593-175478069 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025693	protein coding gene	Chr2:180671398-180681863 (+)
WSB/EiJ	MGP_WSBEiJ_G0026229	protein coding gene	Chr2:185146416-185156892 (+)

Human Ortholog

LSM14B, LSM family member 14B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LSM14B, LSM family member 14B
Synonyms

bA11M20.3, C20orf40, FAM61B, FT005, LSM13, RAP55B
Links

HGNC:15887

NCBI Gene ID: 149986

neXtProt AC: NX_Q9BX40

UniProt: Q9BX40
Chr Location

20q13.33

MGI Vertebrate Homology

Lsm14b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LSM14B
Gene Tree

Lsm14b

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

1
Targeted

5
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit female infertility and oocytes that are incompetent to complete meiosis and early embryogenesis. Male fertility is normal.

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All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

16
cDNA Data

33
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lsm14b

ZFIN lsm14b

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All Sequences

62
RefSeq

23
UniProt

4
CCDS

CCDS17165.2

Ensembl

ENSMUSG00000039108 (Evidence)
NCBI Gene

241846

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039108	Ensembl Gene Model \| MGI Sequence Detail	10479	C57BL/6J	± kb
transcript	ENSMUST00000055485	Ensembl \| MGI Sequence Detail	2534	Not Applicable
polypeptide	ENSMUSP00000055036	Ensembl \| MGI Sequence Detail	385	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009959 protein LSM14 homolog B

(term hierarchy)
InterPro Domains

IPR025762 DFDF domain

IPR019050 FDF domain

IPR025761 FFD box

IPR025609 Lsm14-like, N-terminal

IPR010920 LSM domain superfamily

IPR047575 Sm domain

IPR025768 TFG box
GlyGen

Q8CGC4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 38

Genomic 2

cDNA 33

Primer pair 2

Other 1

Microarray probesets 3

Summaries

All 41

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 12
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:351299 Zhang H, et al., LSM14B coordinates protein component expression in the P-body and controls oocyte maturation. J Genet Genomics. 2024 Jan;51(1):48-60

TSS for Lsm14b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22196	Chr2:179666696-179666707 (+)	-78 bp
Tssr22197	Chr2:179666744-179666800 (+)	-8 bp
Tssr800	Chr2:179667049-179667061 (+)	275 bp
Tssr22198	Chr2:179676403-179676410 (+)	9,627 bp
Tssr22199	Chr2:179676609-179676643 (+)	9,846 bp
Tssr22200	Chr2:179676874-179676878 (+)	10,096 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24