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Prex1 Gene Detail
Summary
  • Symbol
    Prex1
  • Name
    phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
  • Synonyms
    P-REX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3040696
    NCBI Gene: 277360
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:166408265-166555752 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 87.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4856 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3040696
 protein coding gene Chr2:166408262-166555752 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026901
 protein coding gene Chr2:172222794-172378024 (-)
A/J MGP_AJ_G0026867
 protein coding gene Chr2:165158706-165308342 (-)
AKR/J MGP_AKRJ_G0026840
 protein coding gene Chr2:170078600-170224746 (-)
BALB/cJ MGP_BALBcJ_G0026876
 protein coding gene Chr2:165514124-165661490 (-)
C3H/HeJ MGP_C3HHeJ_G0026620
 protein coding gene Chr2:170435426-170586328 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027324
 protein coding gene Chr2:177229495-177387951 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024696
 protein coding gene Chr2:158502991-158652052 (-)
CAST/EiJ MGP_CASTEiJ_G0026078
 protein coding gene Chr2:170879061-171045382 (-)
CBA/J MGP_CBAJ_G0026597
 protein coding gene Chr2:183716287-183880244 (-)
DBA/2J MGP_DBA2J_G0026733
 protein coding gene Chr2:164291121-164440352 (-)
FVB/NJ MGP_FVBNJ_G0026701
 protein coding gene Chr2:162787926-162938319 (-)
LP/J MGP_LPJ_G0026835
 protein coding gene Chr2:172254159-172416111 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026720
 protein coding gene Chr2:187141336-187295825 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027380
 protein coding gene Chr2:169976713-170128423 (-)
PWK/PhJ MGP_PWKPhJ_G0025813
 protein coding gene Chr2:163920913-164073098 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025615
 protein coding gene Chr2:168908863-169082653 (-)
WSB/EiJ MGP_WSBEiJ_G0026149
 protein coding gene Chr2:170887487-171039517 (-)



Homology
more
  • Human Ortholog
    PREX1, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PREX1, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
  • Synonyms
    P-REX1
  • Links
    NCBI Gene ID: 57580
    neXtProt AC: NX_Q8TCU6
    UniProt: Q8TCU6

  • Chr Location
    20q13.13; chr20:48624252-48888185 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Prex1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    2 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have impaired neutrophil migration and autism-like social behavior with defective AMPA-mediated LTD. Mice with other alleles exhibit reduced weight, smaller livers and increased peripheral neutrophil numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    939
  • Tissues
    71
  • cDNA Data
    8
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 277360 NCBI Gene Model | MGI Sequence Detail 147488 C57BL/6J ±  kb
    transcript NM_177782 RefSeq | MGI Sequence Detail 6530 Not Specified  
    polypeptide Q69ZK0 UniProt | EBI | MGI Sequence Detail 1650 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013202 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
      (term hierarchy)
    • InterPro Domains
      IPR000219 Dbl homology (DH) domain
      IPR035899 Dbl homology (DH) domain superfamily
      IPR000591 DEP domain
      IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
      IPR001478 PDZ domain
      IPR036034 PDZ superfamily
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR051832 Regulators of mTOR signaling and Rac activation
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      Q69ZK0 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:346951 Machin PA, et al., Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis. Front Immunol. 2023;14:1180886
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory