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Nlrp2 Gene Detail
Summary
  • Symbol
    Nlrp2
  • Name
    NLR family, pyrin domain containing 2
  • Synonyms
    E330007A02Rik, Nalp2, Nbs1, Pan1, PYPAF2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3041206
    NCBI Gene: 232827
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:5301546-5354034 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 3.07 cM, cytoband A1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1595 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3041206
 protein coding gene Chr7:5301546-5354034 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031590
 protein coding gene Chr7:2301523-2358075 (-)
A/J MGP_AJ_G0031562
 protein coding gene Chr7:2253029-2305101 (-)
AKR/J MGP_AKRJ_G0031491
 protein coding gene Chr7:2350250-2405938 (-)
BALB/cJ MGP_BALBcJ_G0031570
 protein coding gene Chr7:2331609-2383246 (-)
C3H/HeJ MGP_C3HHeJ_G0031291
 protein coding gene Chr7:2312364-2362333 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032032
 protein coding gene Chr7:2329876-2395452 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030654
 protein coding gene Chr7:2221656-2279774 (-)
CBA/J MGP_CBAJ_G0031249
 protein coding gene Chr7:2568642-2623261 (-)
DBA/2J MGP_DBA2J_G0031408
 protein coding gene Chr7:2258999-2327302 (-)
FVB/NJ MGP_FVBNJ_G0031360
 protein coding gene Chr7:2180346-2248486 (-)
LP/J MGP_LPJ_G0031493
 protein coding gene Chr7:2359311-2430744 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031399
 protein coding gene Chr7:2541343-2605839 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032062
 protein coding gene Chr7:2251281-2309275 (-)
PWK/PhJ MGP_PWKPhJ_G0030384
 protein coding gene Chr7:2365108-2417368 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030209
 protein coding gene Chr7:2259806-2305820 (-)
WSB/EiJ MGP_WSBEiJ_G0030751
 protein coding gene Chr7:2269655-2337082 (-)



Homology
more
  • Human Ortholog
    NLRP2, NLR family pyrin domain containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP2, NLR family pyrin domain containing 2
  • Synonyms
    CLR19.9, NALP2, NBS1, OZEMA18, PAN1, PYPAF2
  • Links
    NCBI Gene ID: 55655
    neXtProt AC: NX_Q9NX02
    UniProt: Q9NX02

  • Chr Location
    19q13.42; chr19:54953130-55001142 (+)  GRCh38
  • Human Ortholog
    NLRP7, NLR family pyrin domain containing 7
  • Synonyms
    CLR19.4, HYDM, NALP7, NOD12, PAN7, PYPAF3
  • Links
    NCBI Gene ID: 199713
    neXtProt AC: NX_Q8WX94
    UniProt: Q8WX94

  • Chr Location
    19q13.42; chr19:54923509-54966312 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NLRP7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knockout mice exhibit no overt abnormal phenotypes. Older mice (greater than 15 weeks of age) females mice exhibit reduced fertility with abnormal ovarian follicles, irregularly formed oocytes and decreased fertilization rates.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    31
  • cDNA Data
    9
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232827 NCBI Gene Model | MGI Sequence Detail 52489 C57BL/6J ±  kb
    transcript NM_177690 RefSeq | MGI Sequence Detail 3404 C57BL/6  
    polypeptide NP_808358 RefSeq | MGI Sequence Detail 1046 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR004020 DAPIN domain
      IPR011029 Death-like domain superfamily
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
      IPR007111 NACHT nucleoside triphosphatase
      IPR050637 NLRP family, innate immunity and inflammation regulators
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 9
      Primer pair 2
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 6
      Gene Ontology 2
      Phenotypes 12
    • Earliest
      J:92340 Anderson JP, et al., Structural, expression, and evolutionary analysis of mouse CIAS1. Gene. 2004 Aug 18;338(1):25-34
    • Latest
      J:348425 Pham AH, et al., Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice. Cells. 2024;13(10):802
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory