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Ccdc157 Gene Detail
Summary
  • Symbol
    Ccdc157
  • Name
    coiled-coil domain containing 157
  • Synonyms
    4930562D19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3041210
    NCBI Gene: 216516
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:4091123-4110293 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    452 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3041210
 protein coding gene Chr11:4091123-4110999 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017976
 protein coding gene Chr11:1069075-1090306 (-)
A/J MGP_AJ_G0017949
 protein coding gene Chr11:1084249-1103476 (-)
AKR/J MGP_AKRJ_G0017913
 protein coding gene Chr11:1140090-1159175 (-)
BALB/cJ MGP_BALBcJ_G0017917
 protein coding gene Chr11:1052865-1072644 (-)
C3H/HeJ MGP_C3HHeJ_G0017730
 protein coding gene Chr11:1033057-1052151 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018370
 protein coding gene Chr11:1154106-1173281 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016028
 protein coding gene Chr11:961761-981765 (-)
CAST/EiJ MGP_CASTEiJ_G0017292
 protein coding gene Chr11:999499-1018446 (-)
CBA/J MGP_CBAJ_G0017705
 protein coding gene Chr11:1391693-1414805 (-)
DBA/2J MGP_DBA2J_G0017816
 protein coding gene Chr11:985362-1007182 (-)
FVB/NJ MGP_FVBNJ_G0017807
 protein coding gene Chr11:1020127-1041108 (-)
LP/J MGP_LPJ_G0017886
 protein coding gene Chr11:1177671-1197933 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017833
 protein coding gene Chr11:1065723-1085875 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018409
 protein coding gene Chr11:1141691-1165649 (-)
PWK/PhJ MGP_PWKPhJ_G0017073
 protein coding gene Chr11:991069-1010704 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016869
 protein coding gene Chr11:1093841-1114380 (-)
WSB/EiJ MGP_WSBEiJ_G0017346
 protein coding gene Chr11:1009742-1030238 (-)



Homology
more
  • Human Ortholog
    CCDC157, coiled-coil domain containing 157
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC157, coiled-coil domain containing 157
  • Links
    NCBI Gene ID: 550631
    neXtProt AC: NX_Q569K6
    UniProt: Q569K6

  • Chr Location
    chr22:30356624-30378673 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ccdc157 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males are infertile, exhibit decreased sperm count and motility, malformed sperm heads, misstructured acrosome and abnormal head-tail coupling apparatus in sperm, and irregular nuclei and mis-localized Golgi apparatus in sperm.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051427 Ensembl Gene Model | MGI Sequence Detail 19171 C57BL/6J ±  kb
    transcript ENSMUST00000093381 Ensembl | MGI Sequence Detail 5015 Not Applicable  
    polypeptide ENSMUSP00000091074 Ensembl | MGI Sequence Detail 718 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 34

      Microarray probesets 3
    References
    more
    • Summaries
      All 22
      Diseases 1
      Phenotypes 3
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:346468 Zheng H, et al., CCDC157 is essential for sperm differentiation and shows oligoasthenoteratozoospermia-related mutations in men. J Cell Mol Med. 2024 Apr;28(7):e18215
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory