About   Help   FAQ
Ska3 Gene Detail
Summary
  • Symbol
    Ska3
  • Name
    spindle and kinetochore associated complex subunit 3
  • Synonyms
    F630043A04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3041235
    NCBI Gene: 219114
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:58044018-58063642 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 30.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    629 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3041235
 protein coding gene Chr14:58044016-58063748 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021412
 protein coding gene Chr14:52024868-52045568 (-)
A/J MGP_AJ_G0021373
 protein coding gene Chr14:50976961-50996406 (-)
AKR/J MGP_AKRJ_G0021348
 protein coding gene Chr14:52771172-52790768 (-)
BALB/cJ MGP_BALBcJ_G0021376
 protein coding gene Chr14:50920699-50940290 (-)
C3H/HeJ MGP_C3HHeJ_G0021155
 protein coding gene Chr14:52424380-52446458 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021815
 protein coding gene Chr14:54577103-54599139 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019355
 protein coding gene Chr14:49061797-49078415 (-)
CAST/EiJ MGP_CASTEiJ_G0020673
 protein coding gene Chr14:48767022-48788324 (-)
CBA/J MGP_CBAJ_G0021122
 protein coding gene Chr14:56203473-56225881 (-)
DBA/2J MGP_DBA2J_G0021243
 protein coding gene Chr14:50651866-50671450 (-)
FVB/NJ MGP_FVBNJ_G0021224
 protein coding gene Chr14:50044852-50064419 (-)
LP/J MGP_LPJ_G0021318
 protein coding gene Chr14:53059470-53080102 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021252
 protein coding gene Chr14:55540465-55561342 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021839
 protein coding gene Chr14:51915953-51936506 (-)
PWK/PhJ MGP_PWKPhJ_G0020416
 protein coding gene Chr14:47197368-47217706 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020249
 protein coding gene Chr14:47999521-48021529 (-)
WSB/EiJ MGP_WSBEiJ_G0020725
 protein coding gene Chr14:52235093-52254679 (-)



Homology
more
  • Human Ortholog
    SKA3, spindle and kinetochore associated complex subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SKA3, spindle and kinetochore associated complex subunit 3
  • Synonyms
    C13orf3, RAMA1
  • Links
    NCBI Gene ID: 221150
    neXtProt AC: NX_Q8IX90
    UniProt: Q8IX90

  • Chr Location
    13q12.11; chr13:21153595-21176552 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    14
  • Targeted
    2
  • Genomic Mutations
    1 involving Ska3
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    23 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    8
  • cDNA Data
    10
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021965 Ensembl Gene Model | MGI Sequence Detail 19625 C57BL/6J ±  kb
transcript ENSMUST00000022536 Ensembl | MGI Sequence Detail 2260 Not Applicable  
polypeptide ENSMUSP00000022536 Ensembl | MGI Sequence Detail 411 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013703 spindle and kinetochore-associated protein RAMA1
    (term hierarchy)
  • InterPro Domains
    IPR033341 Spindle and kinetochore-associated protein 3
  • GlyGen
    Q8C263 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 2
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:314146 Gao W, et al., Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis. Cell Death Dis. 2020 Oct 26;11(10):919
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory