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Neurl2 Gene Detail
Summary
  • Symbol
    Neurl2
  • Name
    neuralized E3 ubiquitin protein ligase 2
  • Synonyms
    Ozz, Ozz-E3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3043305
    NCBI Gene: 415115
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164672652-164675376 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.27 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3043305
 protein coding gene Chr2:164672650-164675516 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026878
 protein coding gene Chr2:170335703-170338428 (-)
A/J MGP_AJ_G0026845
 protein coding gene Chr2:163369678-163372402 (-)
AKR/J MGP_AKRJ_G0026816
 protein coding gene Chr2:168244920-168247644 (-)
BALB/cJ MGP_BALBcJ_G0026854
 protein coding gene Chr2:163736205-163738929 (-)
C3H/HeJ MGP_C3HHeJ_G0026596
 protein coding gene Chr2:168591266-168595136 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027301
 protein coding gene Chr2:175269770-175272494 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024672
 protein coding gene Chr2:156776959-156779374 (-)
CAST/EiJ MGP_CASTEiJ_G0026054
 protein coding gene Chr2:169005887-169009854 (-)
CBA/J MGP_CBAJ_G0026573
 protein coding gene Chr2:181632193-181634917 (-)
DBA/2J MGP_DBA2J_G0026711
 protein coding gene Chr2:162536697-162539421 (-)
FVB/NJ MGP_FVBNJ_G0026677
 protein coding gene Chr2:160957310-160960034 (-)
LP/J MGP_LPJ_G0026813
 protein coding gene Chr2:170394155-170396880 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026696
 protein coding gene Chr2:185189555-185192279 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027358
 protein coding gene Chr2:168132048-168134772 (-)
PWK/PhJ MGP_PWKPhJ_G0025791
 protein coding gene Chr2:162137360-162140137 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025592
 protein coding gene Chr2:167031336-167034021 (-)
WSB/EiJ MGP_WSBEiJ_G0026127
 protein coding gene Chr2:169011532-169014256 (-)



Homology
more
  • Human Ortholog
    NEURL2, neuralized E3 ubiquitin protein ligase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEURL2, neuralized E3 ubiquitin protein ligase 2
  • Synonyms
    C20orf163, OZZ, OZZ-E3
  • Links
    NCBI Gene ID: 140825
    neXtProt AC: NX_Q9BR09
    UniProt: Q9BR09

  • Chr Location
    20q13.12; chr20:45888625-45891208 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display myofiber abnormalities in skeletal muscle and decreased body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    3
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039873 Ensembl Gene Model | MGI Sequence Detail 2725 C57BL/6J ±  kb
    transcript ENSMUST00000042775 Ensembl | MGI Sequence Detail 1014 Not Applicable  
    polypeptide ENSMUSP00000041806 Ensembl | MGI Sequence Detail 285 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:40589 Rottier RJ, et al., Identification of the promoters for the human and murine protective protein/cathepsin A genes. DNA Cell Biol. 1997 May;16(5):599-610
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory