Tg(Ins1-Cat,Tyr)25Pne
Transgene Detail

Summary

• Symbol: Tg(Ins1-Cat,Tyr)25Pne
• Name: transgene insertion 25, Paul N Epstein
• MGI ID: MGI:3043843
• Synonyms: RipCat
• Transgene: Tg(Ins1-Cat,Tyr)25Pne Location: unknown
• Alliance: Tg(Ins1-Cat,Tyr)25Pne page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins1-Cat,Tyr)25Pne expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Cat (24248)

  Cat	(MGI:88271)

• Mutation details: The symbol represents a double transgene. In one transgene, a rat insulin I promoter drives the expression of a rat catalase cDNA. Northern blot analysis and immunohistochemistry detected expression of this transgene in pancreatic beta cells. A second transgene that expresses tyrosinase under control of the tyrosinase promoter was coinjected with the first transgene, and apparently cosegregated. (J:59725)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:59725 Xu B, et al., Overexpression of catalase provides partial protection to transgenic mouse beta cells. Free Radic Biol Med. 1999 Oct;27(7-8):830-7
• All: 3 reference(s)