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Cox6b2 Gene Detail
Summary
  • Symbol
    Cox6b2
  • Name
    cytochrome c oxidase subunit 6B2
  • Synonyms
    1700067P11Rik, COXVIB2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3044182
    NCBI Gene: 333182
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4754791-4756093 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3044182
 protein coding gene Chr7:4754791-4756093 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031558
 protein coding gene Chr7:1680792-1682094 (-)
A/J MGP_AJ_G0031532
 protein coding gene Chr7:1688268-1689570 (-)
AKR/J MGP_AKRJ_G0031461
 protein coding gene Chr7:1755242-1756544 (-)
BALB/cJ MGP_BALBcJ_G0031540
 protein coding gene Chr7:1727910-1729212 (-)
C3H/HeJ MGP_C3HHeJ_G0031261
 protein coding gene Chr7:1728338-1729640 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032001
 protein coding gene Chr7:1744959-1746261 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029125
 protein coding gene Chr7:1434112-1435401 (-)
CAST/EiJ MGP_CASTEiJ_G0030625
 protein coding gene Chr7:1671951-1673255 (-)
CBA/J MGP_CBAJ_G0031219
 protein coding gene Chr7:1944350-1945652 (-)
DBA/2J MGP_DBA2J_G0031378
 protein coding gene Chr7:1666604-1667906 (-)
FVB/NJ MGP_FVBNJ_G0031330
 protein coding gene Chr7:1632690-1633992 (-)
LP/J MGP_LPJ_G0031463
 protein coding gene Chr7:1788600-1789902 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031369
 protein coding gene Chr7:1879847-1881149 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032031
 protein coding gene Chr7:1667251-1668553 (-)
PWK/PhJ MGP_PWKPhJ_G0030353
 protein coding gene Chr7:1835744-1837047 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030178
 protein coding gene Chr7:1716815-1718118 (-)
WSB/EiJ MGP_WSBEiJ_G0030720
 protein coding gene Chr7:1684180-1685482 (-)



Homology
more
  • Human Ortholog
    COX6B2, cytochrome c oxidase subunit 6B2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX6B2, cytochrome c oxidase subunit 6B2
  • Synonyms
    COXVIB2, CT59
  • Links
    NCBI Gene ID: 125965
    neXtProt AC: NX_Q6YFQ2
    UniProt: Q6YFQ2

  • Chr Location
    19q13.42; chr19:55349306-55354719 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show reduced male fertility associated with asthenozoospermia but no abnormalities in sperm mitochondrial sheath formation or sperm mitochondrial function. Female fertility is unaffected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    95
  • cDNA Data
    48
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 333182 NCBI Gene Model | MGI Sequence Detail 1303 C57BL/6J ±  kb
    transcript NM_001289848 RefSeq | MGI Sequence Detail 599 Not Specified  
    polypeptide Q80ZN9 UniProt | EBI | MGI Sequence Detail 88 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000005784 cytochrome c oxidase subunit 6B2
      (term hierarchy)
    • InterPro Domains
      IPR003213 Cytochrome c oxidase, subunit VIb
      IPR036549 Cytochrome c oxidase, subunit VIb superfamily
      IPR048280 Cytochrome oxidase c subunit VIb-like
    • GlyGen
      Q80ZN9 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 48

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1925718
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345850 Shimada K, et al., Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility. Exp Anim. 2024 Feb 14;73(1):1-10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory