Wipf3 MGI Mouse Gene Detail - MGI:3044681 - WAS/WASL interacting protein family, member 3

Symbol

Wipf3
Name

WAS/WASL interacting protein family, member 3

Feature Type

protein coding gene
IDs

MGI:3044681
NCBI Gene: 330319
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr6:54406588-54480753 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 26.93 cM
Mapping Data

2 experiments

SNPs within 2kb

2436 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3044681	protein coding gene	Chr6:54406206-54480753 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030760	protein coding gene	Chr6:53781373-53858894 (+)
A/J	MGP_AJ_G0030729	protein coding gene	Chr6:51290948-51366421 (+)
AKR/J	MGP_AKRJ_G0030656	protein coding gene	Chr6:53032643-53109221 (+)
BALB/cJ	MGP_BALBcJ_G0030741	protein coding gene	Chr6:51642649-51717012 (+)
C3H/HeJ	MGP_C3HHeJ_G0030454	protein coding gene	Chr6:53048116-53127500 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031196	protein coding gene	Chr6:54982164-55059615 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028402	protein coding gene	Chr6:48896941-48974297 (+)
CAST/EiJ	MGP_CASTEiJ_G0029857	protein coding gene	Chr6:52894986-52977634 (+)
CBA/J	MGP_CBAJ_G0030428	protein coding gene	Chr6:57242199-57324380 (+)
DBA/2J	MGP_DBA2J_G0030578	protein coding gene	Chr6:51192688-51266776 (+)
FVB/NJ	MGP_FVBNJ_G0030530	protein coding gene	Chr6:50777762-50852677 (+)
LP/J	MGP_LPJ_G0030663	protein coding gene	Chr6:53729415-53804860 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030564	protein coding gene	Chr6:59773621-59862014 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031226	protein coding gene	Chr6:52979784-53059730 (+)
PWK/PhJ	MGP_PWKPhJ_G0029570	protein coding gene	Chr6:50843714-50918631 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029404	protein coding gene	Chr6:52354402-52434772 (+)
WSB/EiJ	MGP_WSBEiJ_G0029934	protein coding gene	Chr6:53008413-53084404 (+)

Human Ortholog

WIPF3, WAS/WASL interacting protein family member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WIPF3, WAS/WASL interacting protein family member 3
Synonyms

CR16
Links

HGNC:22004

NCBI Gene ID: 644150

neXtProt AC: NX_A6NGB9

UniProt: A6NGB9
Chr Location

7p14.3; chr7:29806486-29917061 (+) GRCh38

MGI Vertebrate Homology

Wipf3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WIPF3
Gene Tree

Wipf3

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display impaired spermatogenesis, abnormal sperm head morphology, and significantly reduced male fertility. Female fertility is not affected.

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All GO Annotations

20
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

ZFIN wipf3

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All Sequences

49
RefSeq

10
UniProt

3
CCDS

CCDS51779.1, CCDS51780.1

Ensembl

ENSMUSG00000086040 (Evidence)
NCBI Gene

330319

			Length	Strain/Species	Flank
genomic	ENSMUSG00000086040	Ensembl Gene Model \| MGI Sequence Detail	74166	C57BL/6J	± kb
transcript	ENSMUST00000132855	Ensembl \| MGI Sequence Detail	4516	Not Applicable
polypeptide	ENSMUSP00000120240	Ensembl \| MGI Sequence Detail	483	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017424 WAS/WASL-interacting protein family member 3

(term hierarchy)
InterPro Domains

IPR028290 WASH1

IPR003124 WH2 domain
GlyGen

P0C7L0 1 site, 1 N-linked glycan (1 site)

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All nucleic 4

cDNA 4

Microarray probesets 1

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MGI:2141631

Summaries

All 23

Gene Ontology 5

Phenotypes 5
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:317350 O'Neil SD, et al., Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. Elife. 2021 Jul 16;10:e63756

TSS for Wipf3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56609	Chr6:54406529-54406532 (+)	-57 bp
Tssr56610	Chr6:54406617-54406634 (+)	38 bp
Tssr56611	Chr6:54406638-54406649 (+)	56 bp
Tssr56612	Chr6:54406663-54406679 (+)	83 bp
Tssr56613	Chr6:54408467-54408474 (+)	1,883 bp
Tssr56614	Chr6:54417500-54417503 (+)	10,914 bp
Tssr56615	Chr6:54433185-54433194 (+)	26,602 bp
Tssr56616	Chr6:54437259-54437260 (+)	30,672 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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