Ccdc42 MGI Mouse Gene Detail - MGI:3045254 - coiled-coil domain containing 42

Symbol

Ccdc42
Name

coiled-coil domain containing 42
Synonyms

A530001H01Rik

Feature Type

protein coding gene
IDs

MGI:3045254
NCBI Gene: 276920
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:68477863-68488777 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 41.85 cM
Mapping Data

1 experiment

SNPs within 2kb

401 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045254	protein coding gene	Chr11:68477847-68488792 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018503	protein coding gene	Chr11:68938035-68948070 (+)
A/J	MGP_AJ_G0018472	protein coding gene	Chr11:66364555-66375759 (+)
AKR/J	MGP_AKRJ_G0018441	protein coding gene	Chr11:68337033-68349553 (+)
BALB/cJ	MGP_BALBcJ_G0018443	protein coding gene	Chr11:66652526-66663432 (+)
C3H/HeJ	MGP_C3HHeJ_G0018256	protein coding gene	Chr11:68366606-68378260 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018895	protein coding gene	Chr11:71038818-71050328 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016539	protein coding gene	Chr11:63311693-63321507 (+)
CAST/EiJ	MGP_CASTEiJ_G0017812	protein coding gene	Chr11:68598586-68610222 (+)
CBA/J	MGP_CBAJ_G0018230	protein coding gene	Chr11:74187463-74197827 (+)
DBA/2J	MGP_DBA2J_G0018339	protein coding gene	Chr11:65965043-65975852 (+)
FVB/NJ	MGP_FVBNJ_G0018329	protein coding gene	Chr11:65586246-65597175 (+)
LP/J	MGP_LPJ_G0018410	protein coding gene	Chr11:69514256-69528308 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018352	protein coding gene	Chr11:74896844-74908998 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018936	protein coding gene	Chr11:68584398-68595985 (+)
PWK/PhJ	MGP_PWKPhJ_G0017587	protein coding gene	Chr11:66588766-66598951 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017375	protein coding gene	Chr11:68425223-68435073 (+)
WSB/EiJ	MGP_WSBEiJ_G0017865	protein coding gene	Chr11:68216031-68227765 (+)

Human Ortholog

CCDC42, coiled-coil domain containing 42

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCDC42, coiled-coil domain containing 42
Synonyms

CCDC42A
Links

HGNC:26528

NCBI Gene ID: 146849

neXtProt AC: NX_Q96M95

UniProt: Q96M95
Chr Location

17p13.1; chr17:8729935-8745219 (-) GRCh38

MGI Vertebrate Homology

Ccdc42 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCDC42
Gene Tree

Ccdc42

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Phenotype Summary

17 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

1 involving Ccdc42
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and developmentally normal with no overt behavioral deficits. Males exhibit defects in the number and location of the sperm head-tail coupling apparatus, lack flagellated sperm, and are sterile.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

49
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccdc42

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All Sequences

35
RefSeq

4
UniProt

2
CCDS

CCDS24868.2

Ensembl

ENSMUSG00000045915 (Evidence)
NCBI Gene

276920

			Length	Strain/Species	Flank
genomic	276920	NCBI Gene Model \| MGI Sequence Detail	10915	C57BL/6J	± kb
transcript	NM_177779	RefSeq \| MGI Sequence Detail	1353	C57BL/6
polypeptide	Q5SV66	UniProt \| EBI \| MGI Sequence Detail	316	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030312 coiled-coil domain-containing protein 42

(term hierarchy)
InterPro Domains

IPR051147 Cilia- and flagella-associated domain-containing protein

IPR025252 Domain of unknown function DUF4200

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All nucleic 13

cDNA 13

Microarray probesets 1

Summaries

All 28

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 8
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:344445 Ma Y, et al., CCDC146 is required for sperm flagellum biogenesis and male fertility in mice. Cell Mol Life Sci. 2023 Dec 1;81(1):1

TSS for Ccdc42:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102326	Chr11:68477812-68477856 (+)	-29 bp
Tssr102327	Chr11:68484879-68484890 (+)	7,022 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24