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Wdr25 Gene Detail
Summary
  • Symbol
    Wdr25
  • Name
    WD repeat domain 25
  • Synonyms
    B930090D16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045255
    NCBI Gene: 212198
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:108860155-108994380 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 59.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2946 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045255
 protein coding gene Chr12:108859557-108994380 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020112
 protein coding gene Chr12:111055911-111204481 (+)
A/J MGP_AJ_G0020066
 protein coding gene Chr12:106833777-106970841 (+)
AKR/J MGP_AKRJ_G0020042
 protein coding gene Chr12:109931117-110089437 (+)
BALB/cJ MGP_BALBcJ_G0020052
 protein coding gene Chr12:107254734-107387435 (+)
C3H/HeJ MGP_C3HHeJ_G0019854
 protein coding gene Chr12:110379078-110527780 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020497
 protein coding gene Chr12:114470437-114616258 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018109
 protein coding gene Chr12:103355564-103490511 (+)
CAST/EiJ MGP_CASTEiJ_G0019396
 protein coding gene Chr12:105323356-105468409 (+)
CBA/J MGP_CBAJ_G0019821
 protein coding gene Chr12:119034798-119200499 (+)
DBA/2J MGP_DBA2J_G0019938
 protein coding gene Chr12:106370487-106505051 (+)
FVB/NJ MGP_FVBNJ_G0019923
 protein coding gene Chr12:105161367-105299676 (+)
LP/J MGP_LPJ_G0020013
 protein coding gene Chr12:110919190-111063754 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019961
 protein coding gene Chr12:122174557-122320381 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020526
 protein coding gene Chr12:109415458-109553076 (+)
PWK/PhJ MGP_PWKPhJ_G0019155
 protein coding gene Chr12:100992524-101130177 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018959
 protein coding gene Chr12:103620535-103762642 (+)
WSB/EiJ MGP_WSBEiJ_G0019453
 protein coding gene Chr12:110353586-110496273 (+)



Homology
more
  • Human Ortholog
    WDR25, WD repeat domain 25
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR25, WD repeat domain 25
  • Synonyms
    C14orf67
  • Links
    NCBI Gene ID: 79446
    neXtProt AC: NX_Q64LD2
    UniProt: Q64LD2

  • Chr Location
    14q32.2; chr14:100376418-100530303 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 212198 NCBI Gene Model | MGI Sequence Detail 134226 C57BL/6J ±  kb
    transcript NM_177602 RefSeq | MGI Sequence Detail 2657 C57BL/6  
    polypeptide E9Q349 UniProt | EBI | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 25
      Phenotypes 10
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory