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Lrrd1 Gene Detail
Summary
  • Symbol
    Lrrd1
  • Name
    leucine rich repeats and death domain containing 1
  • Synonyms
    4932412H11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045299
    NCBI Gene: 242838
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:3895173-3916596 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 2.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    621 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045299
 protein coding gene Chr5:3895173-3916596 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029264
 protein coding gene Chr5:665658-690375 (+)
A/J MGP_AJ_G0029229
 protein coding gene Chr5:536512-569399 (+)
AKR/J MGP_AKRJ_G0029177
 protein coding gene Chr5:537503-566401 (+)
BALB/cJ MGP_BALBcJ_G0029246
 protein coding gene Chr5:769680-793525 (+)
C3H/HeJ MGP_C3HHeJ_G0028966
 protein coding gene Chr5:718205-738612 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029695
 protein coding gene Chr5:938445-963424 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026938
 protein coding gene Chr5:572142-589227 (+)
CAST/EiJ MGP_CASTEiJ_G0028378
 protein coding gene Chr5:754557-777651 (+)
CBA/J MGP_CBAJ_G0028928
 protein coding gene Chr5:840403-865374 (+)
DBA/2J MGP_DBA2J_G0029078
 protein coding gene Chr5:694808-716723 (+)
FVB/NJ MGP_FVBNJ_G0029040
 protein coding gene Chr5:600656-624373 (+)
LP/J MGP_LPJ_G0029168
 protein coding gene Chr5:703218-724249 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029067
 protein coding gene Chr5:702616-732269 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029726
 protein coding gene Chr5:666516-694890 (+)
PWK/PhJ MGP_PWKPhJ_G0028099
 protein coding gene Chr5:676778-700261 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027933
 protein coding gene Chr5:955446-978506 (+)
WSB/EiJ MGP_WSBEiJ_G0028458
 protein coding gene Chr5:699510-711544 (+)



Homology
more
  • Human Ortholog
    LRRD1, leucine rich repeats and death domain containing 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRD1, leucine rich repeats and death domain containing 1
  • Links
    NCBI Gene ID: 401387
    neXtProt AC: NX_A4D1F6
    UniProt: A4D1F6

  • Chr Location
    7q21.2; chr7:92141643-92179531 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Male mice for a null allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242838 NCBI Gene Model | MGI Sequence Detail 21424 C57BL/6J ±  kb
    transcript NM_172879 RefSeq | MGI Sequence Detail 2951 C57BL/6  
    polypeptide Q8C0R9 UniProt | EBI | MGI Sequence Detail 853 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000032015 leucine-rich repeat and death domain-containing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR050715 Leucine-rich repeat and signaling effector domain-containing protein
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 20
      Gene Ontology 1
      Phenotypes 3
    • Earliest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
    • Latest
      J:348435 Suzuki A, et al., Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice. J Reprod Immunol. 2024;:104252
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory