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Ankk1 Gene Detail
Summary
  • Symbol
    Ankk1
  • Name
    ankyrin repeat and kinase domain containing 1
  • Synonyms
    9930020N01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045301
    NCBI Gene: 244859
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr9:49326494-49338321 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 26.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    384 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045301
 protein coding gene Chr9:49326494-49338341 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034772
 protein coding gene Chr9:48238825-48254253 (-)
A/J MGP_AJ_G0034753
 protein coding gene Chr9:46800056-46812148 (-)
AKR/J MGP_AKRJ_G0034681
 protein coding gene Chr9:47776858-47788430 (-)
BALB/cJ MGP_BALBcJ_G0034745
 protein coding gene Chr9:46522681-46534212 (-)
C3H/HeJ MGP_C3HHeJ_G0034455
 protein coding gene Chr9:48245982-48258649 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035265
 protein coding gene Chr9:49609726-49623713 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032178
 protein coding gene Chr9:46283069-46294868 (-)
CAST/EiJ MGP_CASTEiJ_G0033777
 protein coding gene Chr9:48180658-48195530 (-)
CBA/J MGP_CBAJ_G0034427
 protein coding gene Chr9:51392303-51405312 (-)
DBA/2J MGP_DBA2J_G0034586
 protein coding gene Chr9:46653358-46665545 (-)
FVB/NJ MGP_FVBNJ_G0034527
 protein coding gene Chr9:45902092-45914172 (-)
LP/J MGP_LPJ_G0034667
 protein coding gene Chr9:48621922-48636312 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034571
 protein coding gene Chr9:53041528-53059505 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035286
 protein coding gene Chr9:47731890-47744123 (-)
PWK/PhJ MGP_PWKPhJ_G0033482
 protein coding gene Chr9:46628658-46641164 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033317
 protein coding gene Chr9:48062693-48074259 (-)
WSB/EiJ MGP_WSBEiJ_G0033890
 protein coding gene Chr9:47761468-47774952 (-)



Homology
more
  • Human Ortholog
    ANKK1, ankyrin repeat and kinase domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANKK1, ankyrin repeat and kinase domain containing 1
  • Synonyms
    PKK2, sgK288
  • Links
    NCBI Gene ID: 255239
    neXtProt AC: NX_Q8NFD2
    UniProt: Q8NFD2

  • Chr Location
    11q23.2; chr11:113387779-113400416 (+)  GRCh38
Human Diseases
more
  • Diseases
    11 with human ANKK1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    848
  • Tissues
    66
  • cDNA Data
    4
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032257 Ensembl Gene Model | MGI Sequence Detail 11828 C57BL/6J ±  kb
transcript ENSMUST00000034792 Ensembl | MGI Sequence Detail 2714 Not Applicable  
polypeptide ENSMUSP00000034792 Ensembl | MGI Sequence Detail 745 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029094 ankyrin repeat and protein kinase domain-containing protein 1
    (term hierarchy)
  • EC
    2.7.11.1
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
    IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
  • GlyGen
    Q8BZ25 3 sites, 1 O-linked glycan (3 sites)
Molecular
Reagents
less
  • All nucleic 5
    cDNA 4
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 23
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 1
  • Earliest
    J:160857 Hoenicka J, et al., The ANKK1 gene associated with addictions is expressed in astroglial cells and upregulated by apomorphine. Biol Psychiatry. 2010 Jan 1;67(1):3-11
  • Latest
    J:267665 Rubio-Solsona E, et al., ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism. PLoS One. 2018;13(5):e0197254
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory