Gluchos1 QTL Detail

Summary

• Symbol
  Gluchos1
• Name
  glucose homeostasis QTL 1

• Feature Type
  QTL
• IDs
  MGI:3046233
  NCBI Gene: 100035795
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 13, 65.32 cM (cM position of peak correlated region/marker)
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 1 genetic background
  15 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  2 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  100035795

References

• Summaries
  All 19

  Phenotypes 15
• Earliest
  J:106692 Toye AA, et al., A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia. 2005 Apr;48(4):675-86
• Latest
  J:357723 Sirbulescu RF, et al., Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis. FASEB J. 2024 Jul 15;38(13):e23796

Candidate Genes for Gluchos1:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Nnt	Chr13:119472063-119545793 (-)	J:109356	Nnt maps to 64 cM on chromosome 13 and was previously identified as a strong candidate gene for Gluchos1. Gluchos1 mapped to 73 cM in an F2 intercross between C57BL/6J (impaired glucose homeostasis) and C3H/HeH (normal glucose homeostasis). C57BL/6J micehave a naturally occurring in-frame deletion of exons 7-11 in Nnt resulting in complete absence of gene product. Transgenic expression of a BAC vector containing a full-length Nnt gene derived from 129S6/SvEvTac in C57BL/6J animals resulted in Nnt protein production levels similar to C3H/HeH and rescue of glucose intolerance and insulin secretion.