Tg(TTR-V30M)15Imeg
Transgene Detail

Summary

• Symbol: Tg(TTR-V30M)15Imeg
• Name: transgene insertion 15, Institute of Molecular Embryology and Genetics
• MGI ID: MGI:3047080
• Synonyms: 6.0-hMet30, 6.0-Met30, Tg(6.0-hV30M)14Imeg, Tg(TTR)15Imeg, Tg(TTR-V30M)15Imeg, Tg(TTR-Val30Met)15Imeg
• Transgene: Tg(TTR-V30M)15Imeg Location: unknown
• Alliance: Tg(TTR-V30M)15Imeg page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TTR-V30M)15Imeg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TTR (7276)

  Ttr	(MGI:98865)

• Mutation details: The targeting construct contained 6.0 kb of the upstream region and the entire coding region of the human transthyretin gene. The coding sequence contained a methionine to valine substitution mutation at position 30. Transgenic transthyretin transcript was detected in liver, brain, kidney, and yolk sac. In some cases aberrant transcript that was larger than normal transcript was detected. (J:91391)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Of the eight transgenic lines produced in J:91391, 5 produced serum levels of transthyretin that were higher than those found in patients with familial amyloidotic polyneuropathy (FAP), these were lines: 15, 21, 24, 37 and 40.

References

• Original: J:91391 Nagata Y, et al., A 6-kb upstream region of the human transthyretin gene can direct developmental, tissue-specific, and quantitatively normal expression in transgenic mouse. J Biochem. 1995 Jan;117(1):169-75
• All: 18 reference(s)