Tg(TcraTcrb)8Rest
Transgene Detail

Summary

• Symbol: Tg(TcraTcrb)8Rest
• Name: transgene insertion 8, Nicholas Restifo
• MGI ID: MGI:3051150
• Synonyms: Pmel-1, pmel-17, Pmel-I
• Transgene: Tg(TcraTcrb)8Rest Location: unknown Genetic Position: Chr2, Syntenic
• Alliance: Tg(TcraTcrb)8Rest page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraTcrb)8Rest expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: These coinjected transgenes encode an H2-D^b-restricted Valpha1 Vbeta13 T-cell receptor that recognizes a peptide comprising amino acids 25-33 of the protein known as pmel-17/gp100, a pigment biosynthetic enzyme that is encoded by the mouse Si (silver) gene and is expressed both in normal melanocytes and in malignant melanoma. The insertion is accompanied by a 157-bp deletion (chr2: 68,208,872?68,209,029 bp - build unknown). (J:85058, J:208902)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:85058 Overwijk WW, et al., Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells. J Exp Med. 2003 Aug 18;198(4):569-80
• All: 168 reference(s)