Igdmr Other Genome Feature Detail

Summary

• Symbol
  Igdmr
• Name
  intergenic germline-derived differentially methylated region
• Synonyms
  IG-DMR, Rr197

• Feature Type
  imprinting control region
• IDs
  MGI:3051678

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• 4156bp SacI-ScaI fragment located at 109492765-109496915 (GRCm39) (excluding restriction sites)

• Genetic Map
  Chromosome 12, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  13 phenotype references
  

• All Mutations and Alleles
  7
• Endonuclease-mediated
  6
• Targeted
  1
• Find Mice (IMSR)
  2 strains or lines available

Heterozygous mutants that carry a maternally inherited mutant allele display embryonic or perinatal lethality, while heterozygous mutants that carry a paternally inherited mutant allele are viable.

Other
Accession IDs

MGI:7286216

References

• Summaries
  All 14

  Phenotypes 13
• Earliest
  J:91849 Lin SP, et al., Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Nat Genet. 2003 Sep;35(1):97-102
• Latest
  J:331751 Weinberg-Shukron A, et al., Balanced gene dosage control rather than parental origin underpins genomic imprinting. Nat Commun. 2022 Jul 29;13(1):4391