Igdmr Other Genome Feature Detail

Summary

• Symbol
  Igdmr
• Name
  intergenic germline-derived differentially methylated region
• Synonyms
  IG-DMR, Rr197

• Feature Type
  imprinting control region
• IDs
  MGI:3051678
• Cluster Members
  Rr198, Rr199, Rr200 (3 members)
• Regulates expression of
  Dlk1, Meg3, Rtl1 ... (8 regulated genes)

Location &
Maps

• Sequence Map
  Chr12:109492765-109496915 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• 4156bp SacI-ScaI fragment located at 109492765-109496915 (GRCm39) (excluding restriction sites)

• Genetic Map
  Chromosome 12, Syntenic

Strain
Comparison

• SNPs within 2kb
  183 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  13 phenotype references
  

• All Mutations and Alleles
  7
• Endonuclease-mediated
  6
• Targeted
  1
• Find Mice (IMSR)
  2 strains or lines available

Heterozygous mutants that carry a maternally inherited mutant allele display embryonic or perinatal lethality, while heterozygous mutants that carry a paternally inherited mutant allele are viable.

Other
Accession IDs

MGI:7286216

References

• Summaries
  All 14

  Phenotypes 13
• Earliest
  J:91849 Lin SP, et al., Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Nat Genet. 2003 Sep;35(1):97-102
• Latest
  J:331751 Weinberg-Shukron A, et al., Balanced gene dosage control rather than parental origin underpins genomic imprinting. Nat Commun. 2022 Jul 29;13(1):4391

Igdmr regulates expression of:

Feature	Feature Type	Location	Reference
Dlk1, delta like non-canonical Notch ligand 1	protein coding gene	Chr12:109418749-109429262 (+)	J:91849
Meg3, maternally expressed 3	lncRNA gene	Chr12:109506879-109538163 (+)	J:91849
Rtl1, retrotransposon Gaglike 1	protein coding gene	Chr12:109555627-109566764 (-)	J:91849
Mir127, microRNA 127	miRNA gene	Chr12:109559280-109559349 (+)	J:91849
AF357425, snoRNA AF357425	snoRNA gene	Chr12:109602446-109602514 (+)	J:91849
AF357426, snoRNA AF357426	snoRNA gene	Chr12:109609272-109609338 (+)	J:91849
AF357428, snoRNA AF357428	snoRNA gene	Chr12:109646379-109646447 (+)	J:91849
Dio3, deiodinase, iodothyronine type III	protein coding gene	Chr12:110245664-110247531 (+)	J:91849

Igdmr Cluster contains:

More Data for these features

Member	Feature Type	Location
Rr198, regulatory region 198	imprinting control region	Chr12:109489982-109490419
Rr199, regulatory region 199	imprinting control region	Chr12:109490399-109490690
Rr200, regulatory region 200	imprinting control region	Chr12:109498268-109498626