Summary |
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Transgene origin |
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Transgene description |
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Phenotypes |
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View phenotypes and curated references for all genotypes (concatenated display).
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Disease models |
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Find Mice (IMSR) |
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Notes |
Overexpression of H2-Ea in line 5 confers nearly complete resistance to IDDM. Although the presence of the transgene in both lines 5 and 12 confers protective influence from IDDM pathologies that affect pancreatic beta cells, autoimmune pathologies effecting other tissues (submandibular salivary, thyroid, kidney) are observed. Histologic examination of the pancreas reveals perivascular/periductal infiltration and peri-insulitus.
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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