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Noto Gene Detail
Summary
  • Symbol
    Noto
  • Name
    notochord homeobox
  • Synonyms
    Flh, MmNot, Not, tc
  • Feature Type
    protein coding gene
  • IDs
    MGI:3053002
    NCBI Gene: 384452
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:85400868-85405859 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.44 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3053002
 protein coding gene Chr6:85400851-85405859 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030952
 protein coding gene Chr6:86589394-86595480 (+)
A/J MGP_AJ_G0030921
 protein coding gene Chr6:83291825-83297320 (+)
AKR/J MGP_AKRJ_G0030849
 protein coding gene Chr6:85704631-85709533 (+)
BALB/cJ MGP_BALBcJ_G0030931
 protein coding gene Chr6:83284516-83289493 (+)
C3H/HeJ MGP_C3HHeJ_G0030779
 protein coding gene Chr6:98735616-98741437 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031391
 protein coding gene Chr6:88972442-88979979 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028576
 protein coding gene Chr6:81565700-81571014 (+)
CAST/EiJ MGP_CASTEiJ_G0030040
 protein coding gene Chr6:85719502-85724383 (+)
CBA/J MGP_CBAJ_G0030618
 protein coding gene Chr6:92462324-92469101 (+)
DBA/2J MGP_DBA2J_G0030771
 protein coding gene Chr6:82575132-82580451 (+)
FVB/NJ MGP_FVBNJ_G0030724
 protein coding gene Chr6:81777693-81782796 (+)
LP/J MGP_LPJ_G0030850
 protein coding gene Chr6:86584317-86591081 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030760
 protein coding gene Chr6:96668345-96673768 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031415
 protein coding gene Chr6:85506678-85511589 (+)
PWK/PhJ MGP_PWKPhJ_G0029755
 protein coding gene Chr6:81510310-81515681 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029583
 protein coding gene Chr6:84360365-84366242 (+)
WSB/EiJ MGP_WSBEiJ_G0030121
 protein coding gene Chr6:85952361-85957254 (+)



Homology
more
  • Human Ortholog
    NOTO, notochord homeobox
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOTO, notochord homeobox
  • Links
    NCBI Gene ID: 344022
    neXtProt AC: NX_A8MTQ0
    UniProt: A8MTQ0

  • Chr Location
    2p13.2; chr2:73202574-73212513 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 7 genetic backgrounds
    7 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice display decreased tail length, a truncated or disrupted notochord, abnormal and missing vertebrae, occasional hindlimb paralysis and postnatal lethality, and abnormal somite and sclerotome development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    29
  • cDNA Data
    7
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068302 Ensembl Gene Model | MGI Sequence Detail 4992 C57BL/6J ±  kb
    transcript ENSMUST00000089578 Ensembl | MGI Sequence Detail 1602 Not Applicable  
    polypeptide ENSMUSP00000087006 Ensembl | MGI Sequence Detail 240 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 1
      Other 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-14735, MGI:98498
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 20
      Gene Ontology 11
      Phenotypes 31
    • Earliest
      J:14910 Theiler K, Boneless tail, ein rezessives autosomales Gen der Hausmaus. Arch Julius Klaus Stift Vererbungsforsch Sozialanthropol Rassenhyg. 1957;32:474-481
    • Latest
      J:343751 Ling Z, et al., Parathyroid hormone treatment partially reverses endplate remodeling and attenuates low back pain in animal models of spine degeneration. Sci Transl Med. 2023 Nov 15;15(722):eadg8982
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory