Tg(TNF)197Gkl
Transgene Detail

Summary

• Symbol: Tg(TNF)197Gkl
• Name: transgene insertion 197, George Kollias
• MGI ID: MGI:3053711
• Synonyms: hTNFtg, Tg197, Tg197 hTNFtg
• Transgene: Tg(TNF)197Gkl Location: unknown
• Alliance: Tg(TNF)197Gkl page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TNF)197Gkl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TNF (7124)

  Tnf	(MGI:104798)

• Mutation details: The transgene comprises the human tumor necrosis factor gene with its 3' UTR, polyadenylation signal and flanking sequence replaced by those of the human hemoglobin beta (HBB) gene. This modification interferes with posttranscriptional regulation of TNF expression, altering expression levels and timing, but apparently not its tissue specificity. Line 197 carries approximately 5 tandemly-arrayed copies of the transgene. (J:92576)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:92576 Keffer J, et al., Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J. 1991 Dec;10(13):4025-31
• All: 51 reference(s)