Tg(ML5sHEL)5Ccg
Transgene Detail

Summary

• Symbol: Tg(ML5sHEL)5Ccg
• Name: transgene insertion 5, Christopher C Goodnow
• MGI ID: MGI:2384160
• Synonyms: MD5, ML-5, ML5, sHEL, solHEL, SWHEL
• Transgene: Tg(ML5sHEL)5Ccg Location: unknown
• Alliance: Tg(ML5sHEL)5Ccg page

Transgene origin

• Strain of Origin: C57BL/6JSfd

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ML5sHEL)5Ccg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  chicken	LYZ (396218)

• Mutation details: A genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to a mouse metallothionein I promoter. The mouse metallothionein I promoter is active during embryonic, fetal, and adult life, and can be induced to higher levels of transcription by heavy metals. Mice carrying the transgene had measurable, soluble chicken lysozyme in their serum. The line chosen for study (ML-5) had the highest serum lysozyme concentrations. (J:78308)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:78308 Goodnow CC, et al., Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature. 1988 Aug 25;334(6184):676-82
• All: 93 reference(s)