Tg(WapMyc)212Bri
Transgene Detail

Summary

• Symbol: Tg(WapMyc)212Bri
• Name: transgene insertion 212, Ralph L Brinster
• MGI ID: MGI:3054251
• Synonyms: TgN(WapMyc)212Bri, WAP-c-myc line 3507-1
• Transgene: Tg(WapMyc)212Bri Location: unknown
• Alliance: Tg(WapMyc)212Bri page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(WapMyc)212Bri expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myc (MGI:97250)

• Mutation details: The transgene contains the mouse whey acidic protein (WAP) promoter and the mouse myelocytomatosis oncogene (Myc). (J:56318)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Tg(WapMyc)212Bri/0 Tg(WapTgfa)215Bri/0	involves: C57BL/6 * SJL
tg2	Tg(WapMyc)212Bri/0	FVB.Cg-Tg(WapMyc)212Bri
tg3	Tg(WapMyc)212Bri/0	involves: C57BL/6 * SJL

Phenotypes:

Affected Systems	cx1		tg2		tg3
show or hide all annotated terms Sex:
endocrine/exocrine glands	√	√	√	√	√	√
abnormal mammary gland morphology			√
abnormal involution of the mammary gland	√
mammary gland duct hyperplasia			√
abnormal mammary gland lobule morphology			√
mammary gland alveolar hyperplasia					√
increased mammary gland tumor incidence	√	√	√	√	√	√
increased mammary adenocarcinoma incidence					√	√
mammary gland hyperplasia	√		√
abnormal lactation	√
lactation failure					√
integument	√	√	√	√	√	√
abnormal mammary gland morphology			√
abnormal involution of the mammary gland	√
mammary gland duct hyperplasia			√
abnormal mammary gland lobule morphology			√
mammary gland alveolar hyperplasia					√
increased mammary gland tumor incidence	√	√	√	√	√	√
increased mammary adenocarcinoma incidence					√	√
mammary gland hyperplasia	√		√
abnormal lactation	√
lactation failure					√
mortality/aging	√	√			√	√
premature death	√	√			√	√
neoplasm	√	√	√	√	√	√
increased mammary gland tumor incidence	√	√	√	√	√	√
increased mammary adenocarcinoma incidence					√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(WapMyc)212Bri

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:56318 Sandgren EP, et al., Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice. Cancer Res. 1995 Sep 1;55(17):3915-27
• All: 10 reference(s)