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Tg(WapMyc)212Bri
Transgene Detail
Summary
Symbol: Tg(WapMyc)212Bri
Name: transgene insertion 212, Ralph L Brinster
MGI ID: MGI:3054251
Synonyms: TgN(WapMyc)212Bri, WAP-c-myc line 3507-1
Transgene: Tg(WapMyc)212Bri  Location: unknown  
Alliance: Tg(WapMyc)212Bri page
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(WapMyc)212Bri expresses 1 gene
 
Mutation detailsThe transgene contains the mouse whey acidic protein (WAP) promoter and the mouse myelocytomatosis oncogene (Myc). (J:56318)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: C57BL/6 * SJL
 
 
involves: C57BL/6 * SJL
 
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
endocrine/exocrine glands
abnormal mammary gland morphology
abnormal involution of the mammary gland
mammary gland duct hyperplasia
abnormal mammary gland lobule morphology
mammary gland alveolar hyperplasia
increased mammary gland tumor incidence
increased mammary adenocarcinoma incidence
mammary gland hyperplasia
abnormal lactation
lactation failure
integument
abnormal mammary gland morphology
abnormal involution of the mammary gland
mammary gland duct hyperplasia
abnormal mammary gland lobule morphology
mammary gland alveolar hyperplasia
increased mammary gland tumor incidence
increased mammary adenocarcinoma incidence
mammary gland hyperplasia
abnormal lactation
lactation failure
mortality/aging
premature death
neoplasm
increased mammary gland tumor incidence
increased mammary adenocarcinoma incidence
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tg(WapMyc)212Bri
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:56318 Sandgren EP, et al., Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice. Cancer Res. 1995 Sep 1;55(17):3915-27
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory