Tg(CD2-Il2rg)M2-1Ttg
Transgene Detail
|
Symbol: |
Tg(CD2-Il2rg)M2-1Ttg |
Name: |
transgene insertion M2-1, Tadatsugu Taniguchi |
MGI ID: |
MGI:3054536 |
Synonyms: |
Il2rgM2, IL2Rg M2, Tg(CD2-Il2rg-deltaGln322-Ala369)1Ttg, Tg(Il2rg)M2 |
Transgene: |
Tg(CD2-Il2rg)M2-1Ttg Location: unknown
|
Alliance: |
Tg(CD2-Il2rg)M2-1Ttg page
|
|
Strain of Origin: |
Not Specified
|
|
Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(CD2-Il2rg)M2-1Ttg expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Il2rg (MGI:96551) |
|
|
|
|
Mutation details: A cDNA encoding mouse IL2RG lacking the carboxyl-terminal 48 amino acids of the 85-amino acid cytoplasmic domain was inserted into an expression vector containing 5 kb of 5' flanking sequence, including the promoter, transcription initiation site and first intron, and 5.5 kb of 3' flanking sequence including the locus control region (LCR) of the human CD2 gene. The transgene product was found to be expressed on CD4+ CD8+ thymocytes and on splenic and peripheral blood T lymphocytes.
(J:92739)
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:92739 Tsujino S, et al., Critical role of the membrane-proximal, proline-rich motif of the interleukin-2 receptor gammac chain in the Jak3-independent signal transduction. Genes Cells. 1999 Jun;4(6):363-73 |
All: |
1 reference(s) |
|